An injectable molecular hydrogel assembled by antimicrobial peptide PAF26 for antimicrobial application.
An injectable molecular hydrogel assembled by antimicrobial peptide PAF26 for antimicrobial application.
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由抗菌肽PAF26组装的可注射分子水凝胶用于抗菌应用
DOI：
10.1039/c9ra06130d
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发表时间：
2019-09-26
期刊：
影响因子：
3.9
通讯作者：
Zhang, Xueli
中科院分区：
文献类型：
--
作者：
Cao, Fengyi;Mei, Lin;Zhu, Genxing;Song, Meng;Zhang, Xueli
伤口感染是抑制伤口恢复的重要因素。利用抗菌生物材料抑制微生物生长是解决这一问题的可行措施。本文研究了两亲抗菌肽（Ac-RKKWFW-NH2, PAF26）形成抗菌水凝胶。在pH触发下，PAF26肽可自组装成水凝胶，形成的水凝胶可注射且具有剪切疏化能力。抗菌实验表明，自组装水凝胶通过破坏细胞膜结构，对白色念珠菌、金黄色葡萄球菌、大肠杆菌等病原微生物具有显著的抗菌能力。因此，本研究提供了一种制备用于抗菌治疗的可注射抗菌肽水凝胶的新方法。研究了六抗菌PAF26肽形成自组装水凝胶的方法。该水凝胶可注射，具有良好的抗菌性能。
Wound infection is a crucial factor that inhibits wound recovery. A feasible measure to solve this problem is using antimicrobial biomaterials to suppress the microbial growth. In this work, an amphipathic antimicrobial peptide (Ac-RKKWFW-NH2, PAF26) was investigated to form the antimicrobial hydrogel. Triggered by pH, PAF26 peptide could self-assemble into a hydrogel, and the hydrogel formed was injectable and exhibited shear-thinning ability. Antimicrobial experiments demonstrated that the self-assembled hydrogel had an outstanding antimicrobial ability against pathogenic microbes such as Candida albicans, Staphylococcus aureus, and Escherichia coli via destroying the cell membrane structure. Thus, this study provides a novel method for preparing an injectable antimicrobial peptide hydrogel for antimicrobial therapies. A hexa-antimicrobial PAF26 peptide was investigated to form a self-assembled hydrogel. The hydrogel was injectable and had an outstanding antimicrobial ability.
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