Endocrine disrupters: A human risk?
Endocrine disrupters: A human risk?
复制标题
内分泌干扰物：人类风险？
DOI：
10.1016/j.mce.2005.02.007
复制
发表时间：
2005
影响因子：
4.1
通讯作者：
R. Harris
中科院分区：
文献类型：
--
作者：
R. Waring;R. Harris
内分泌干扰物（ED）改变正常的激素调节，可能是自然发生的或环境污染物。传统上，ED在基因组上起作用，对类固醇受体具有激动或拮抗作用，并可能通过与雌激素或雄激素受体结合而改变生殖功能和/或引起女性化;它们与甲状腺受体的结合可能使神经内分泌系统失调。最近，它已被证明，ED也可以通过非基因组机制，改变类固醇合成（抑制细胞色素P450亚型）或类固醇代谢。烷基酚和邻苯二甲酸酯增塑剂通过硫酸化（通过SULT 1A 1和1 E1亚型）抑制雌激素的失活，从而导致游离活性内源性雌激素水平升高。一系列艾德效应已在哺乳动物、鱼类、鸟类、爬行动物、两栖动物和水生无脊椎动物中显示，但尚不清楚这些过程是否也发生在人类中。很明显，ED以及改变生殖，可以引起神经类固醇水平的变化，因此有可能影响免疫功能，行为和记忆。这可能是一个长期的问题，因为微量的ED，如增塑剂，溴化阻燃剂，防晒剂和化妆品成分广泛分布在环境和人类生物流体中。
Endocrine disrupters (EDs) alter normal hormonal regulation and may be naturally occurring or environmental contaminants. Classically, EDs act genomically, with agonistic or antagonistic effects on steroid receptors and may alter reproductive function and/or cause feminisation by binding to oestrogen or androgen receptors; their binding to the thyroid receptor may dysregulate the neuroendocrine system. Recently, it has been shown that EDs can also act by non-genomic mechanisms, altering steroid synthesis (inhibition of cytochrome P450 isoforms) or steroid metabolism. The alkylphenol and phthalate plasticisers inhibit the inactivation of oestrogens by sulphation (via SULT 1A1 and 1E1 isoforms) and so cause a rise in levels of the free active endogenous oestrogens. A range of ED effects have been shown in mammals, fish, birds, reptiles, amphibia and aquatic invertebrates but it is not yet clear whether these processes also occur in human beings. It is evident that EDs, as well as altering reproduction, can cause changes in neurosteroid levels and so have the potential to affect immune function, behaviour and memory. This may be of long-term concern since traces of EDs such as plasticisers, brominated fire retardants, sunscreen agents and cosmetic ingredients are widely distributed in the environment and in human biofluids.
影响因子：
3.8
作者：
D. D. Wormley-D.;A. Ramesh;D. Hood
通讯作者：
D. D. Wormley-D.;A. Ramesh;D. Hood
DOI：
10.1073/pnas.0305977101
发表时间：
2004-01-20
影响因子：
11.1
作者：
Akingbemi, BT;Ge, RS;Hardy, MP
通讯作者：
Hardy, MP
香豆雌酚和相关异黄酮类化合物在啮齿动物中的神经行为作用。
影响因子：
2.9
作者：
Whitten,PatriciaL;Patisaul,HeatherB;Young,LarryJ
通讯作者：
Young,LarryJ