TREATMENT OF INTRAOCULAR INFLAMMATORY DISEASE WITH CYCLOSPORIN A
TREATMENT OF INTRAOCULAR INFLAMMATORY DISEASE WITH CYCLOSPORIN A
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用环孢菌素 A 治疗眼内炎症性疾病
DOI：
10.1016/s0140-6736(83)90230-1
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
I. Gery
中科院分区：
文献类型：
--
作者：
R. Nussenblatt;A. Rook;W. Wacker;A. Palestine;I. Scher;I. Gery
8例非感染性病因的双侧威胁视力的后葡萄膜炎患者，对皮质类固醇或细胞毒性治疗无反应，给予环孢菌素A。8例患者中有7例视力改善，眼部炎症活动消失。这7名患者中有2名患有白塞病，他们的非眼部症状也有所改善。来自7名环孢菌素A反应患者的外周血淋巴细胞，而不是来自非反应者的外周血淋巴细胞，对视网膜S抗原（一种高度致葡萄膜炎的器官特异性材料）产生了阳性体外胚细胞生成反应。在4名患者中，OKT 4/OKT 8比值在治疗开始后下降，这是OKT 8分数增加的结果。在其他4名患者中，下降之前OKT 4/OKT 8比值增加。环孢菌素A不影响自然杀伤细胞活性。环孢菌素A的副作用可以耐受或随着持续治疗而消失，有时以较低的剂量。未观察到肿瘤。环孢霉素A似乎是有效的治疗选定的患者与严重的非感染性葡萄膜炎的病因。
Eight patients with bilateral sight-threatening posterior uveitis of non-infectious aetiology that had not responded to corticosteroid or cytotoxic therapy were given cyclosporin A. Seven of the eight responded with improvement in visual acuity and disappearance of ocular inflammatory activity. The seven included two with Behçet's disease, who also had improvement in non-ocular symptoms. Peripheral blood lymphocytes from the seven cyclosporin A responsive patients, but not those from the non-responder, gave positive in-vitro blastogenic responses to the retinal S-antigen, a highly uveitogenic organ-specific material. In four patients OKT4/OKT8 ratios fell after the start of therapy, as the result of an increase in the OKT8 fraction. In the other four patients the fall was preceded by an increase in the OKT4/OKT8 ratio. Cyclosporin A did not influence natural killer cell activity. Side-effects ascribed to cyclosporin A were tolerated or disappeared with continued therapy, sometimes at a lower dosage. No neoplasms were observed. Cyclosporin A seems to be effective treatment for selected patients with severe bilateral uveitis of non-infectious aetiology.
影响因子：
158.5
作者：
QUINNAN, GV;KIRMANI, N;BURNS, WH
通讯作者：
BURNS, WH