In vivo reference point indentation reveals positive effects of raloxifene on mechanical properties following 6 months of treatment in skeletally mature beagle dogs.
In vivo reference point indentation reveals positive effects of raloxifene on mechanical properties following 6 months of treatment in skeletally mature beagle dogs.
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DOI：
10.1016/j.bone.2013.07.009
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发表时间：
2013-10
期刊：
影响因子：
4.1
通讯作者：
Allen, Matthew R.
中科院分区：
文献类型：
--
作者：
Aref, Mohammad;Gallant, Maxime A.;Organ, Jason M.;Wallace, Joseph M.;Newman, Christopher L.;Burr, David B.;Brown, Drew M.;Allen, Matthew R.
雷洛昔芬治疗在骨骼成熟的狗身上治疗一年后，已经被证明对骨机械性能有积极的影响。参考点压痕(RPI)可用于体内机械性能的评估，并已被证明产生的值与传统机械测试得出的性能高度相关。这项研究的目的是使用RPI来确定雷洛昔芬在治疗6个月后是否会导致机械性能的改变。12只成年雌性比格犬分别口服生理盐水(VEH，1ml/kg/d)或临床相关剂量的雷洛昔芬(Raloxifene，Ral，0.5 mg/kg/d)治疗6个月。在6个月时，所有动物接受了活体RPI(10N力，10个循环)。RPI数据使用定制的MatLab程序进行分析，该程序旨在提供来自RPI测试的逐个周期的数据，并根据制造商提供的软件进行验证。压痕距离增加(Idi)是一个与骨骼韧性成反比的参数，与VEH(−16.5%)相比，RAL治疗的动物显著更低，这表明骨骼韧性增加。与VEH相比，第一个周期内的能量吸收显著降低(−为21%)。这些数据建立在以前的工作的基础上，该工作证明了雷洛昔芬对材料性能的积极影响，表明这些变化在6个月后存在。
Raloxifene treatment has been shown previously to positively affect bone mechanical properties following 1 year of treatment in skeletally mature dogs. Reference point indentation (RPI) can be used for in vivo assessment of mechanical properties and has been shown to produce values that are highly correlated with properties derived from traditional mechanical testing. The goal of this study was to use RPI to determine if raloxifene-induced alterations in mechanical properties occurred after 6 months of treatment. Twelve skeletally mature female beagle dogs were treated for 6 months with oral doses of saline vehicle (VEH, 1 ml/kg/day) or a clinically relevant dose of raloxifene (RAL, 0.5 mg/kg/day). At 6 months, all animals underwent in vivo RPI (10 N force, 10 cycles) of the anterior tibial midshaft. RPI data were analyzed using a custom MATLAB program, designed to provide cycle-by-cycle data from the RPI test and validated against the manufacturer-provided software. Indentation distance increase (IDI), a parameter that is inversely related to bone toughness, was significantly lower in RAL-treated animals compared to VEH (− 16.5%), suggesting increased bone toughness. Energy absorption within the first cycle was significantly lower with RAL compared to VEH (− 21%). These data build on previous work that has documented positive effects of raloxifene on material properties by showing that these changes exist after 6 months.
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影响因子：
168.9
作者：
Kanis, JA
通讯作者：
Kanis, JA
影响因子：
4.8
作者：
Allen, Matthew R.;Hogan, Harry A.;Burr, David B.
通讯作者：
Burr, David B.
影响因子：
6.2
作者：
Gueerri-Fernandez, Roberto C.;Nogues, Xavier;Diez-Perez, Adolfo
通讯作者：
Diez-Perez, Adolfo
影响因子：
6.2
作者：
Diez-Perez, Adolfo;Guerri, Roberto;Nogues, Xavier;Caceres, Enric;Jesus Pena, Maria;Mellibovsky, Leonardo;Randall, Connor;Bridges, Daniel;Weaver, James C.;Proctor, Alexander;Brimer, Davis;Koester, Kurt J.;Ritchie, Robert O.;Hansma, Paul K.
通讯作者：
Hansma, Paul K.
影响因子：
6.2
作者：
Allen, Matthew R.;Kubek, Daniel I.;Burr, David B.
通讯作者：
Burr, David B.