Interaction of Age and Self-reported Physical Sports Activity on White Matter Hyperintensity Volume in Healthy Older Adults.
Interaction of Age and Self-reported Physical Sports Activity on White Matter Hyperintensity Volume in Healthy Older Adults.
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DOI：
10.3389/fnagi.2020.576025
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发表时间：
2020
影响因子：
4.8
通讯作者：
Alexander GE
中科院分区：
文献类型：
--
作者：
Franchetti MK;Bharadwaj PK;Nguyen LA;Van Etten EJ;Klimentidis YC;Hishaw GA;Trouard TP;Raichlen DA;Alexander GE
脑白色病变负荷（通过磁共振成像（MRI）测量的白色高信号（WMH）体积）与年龄增加和心血管危险因素（如高血压）相关。在健康老龄化的背景下，体育活动（PSA）可能在维持WM方面发挥重要作用。在196名健康的老年人中，我们调查了报告高水平PSA的参与者（n = 36）与报告低水平PSA的参与者（n = 160）相比，是否减少了总的和区域的WMH体积。以性别、高血压和体重指数（BMI）作为协变量，检验了年龄组[年龄-老年（YO）= 50-69岁;老年（OO）= 70-89岁]、PSA组和年龄-PSA组的相互作用效应。我们发现年龄组和年龄PSA组的总，额，颞，顶叶WMH体积的相互作用显着的主效应。PSA组对WMH体积无主要影响。低PSA的OO组的总WMH体积、额部WMH体积、颞部WMH体积和顶叶WMH体积均大于低PSA的YO组和高PSA的OO组。高PSA的YO和OO组的WMH体积相当。这些结果表明，低PSA人群中存在年龄组差异，老年人的WMH体积较大，而高PSA人群中未观察到。结果表明，从事高水平的PSA可能是一个重要的生活方式因素，可以帮助减少老年WMH病变负荷，可能减少大脑老化的影响。
Cerebral white matter (WM) lesion load, as measured by white matter hyperintensity (WMH) volume with magnetic resonance imaging (MRI), has been associated with increasing age and cardiovascular risk factors, like hypertension. Physical sports activity (PSA) may play an important role in maintaining WM in the context of healthy aging. In 196 healthy older adults, we investigated whether participants reporting high levels of PSA (n = 36) had reduced total and regional WMH volumes compared to those reporting low levels of PSA (n = 160). Age group [young-old (YO) = 50–69 years; old-old (OO) = 70–89 years], PSA group, and age by PSA group interaction effects were tested, with sex, hypertension, and body mass index (BMI) as covariates. We found significant main effects for age group and age by PSA group interactions for total, frontal, temporal, and parietal WMH volumes. There were no main effects of PSA group on WMH volumes. The OO group with low PSA had greater total, frontal, temporal, and parietal WMH volumes than the YO with low PSA and OO with high PSA groups. WMH volumes for the YO and OO groups with high PSA were comparable. These findings indicate an age group difference in those with low PSA, with greater WMH volumes in older adults, which was not observed in those with high PSA. The results suggest that engaging in high levels of PSA may be an important lifestyle factor that can help to diminish WMH lesion load in old age, potentially reducing the impact of brain aging.
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DOI：
10.1136/bmj.c3666
发表时间：
2010-07-26
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Debette S;Markus HS
通讯作者：
Markus HS
影响因子：
5.7
作者：
Fischl, B;Sereno, MI;Dale, AM
通讯作者：
Dale, AM
影响因子：
4.2
作者：
Alexander GE;Bergfield KL;Chen K;Reiman EM;Hanson KD;Lin L;Bandy D;Caselli RJ;Moeller JR
通讯作者：
Moeller JR
影响因子：
3.7
作者：
Burzynska, Agnieszka Zofia;Chaddock-Heyman, Laura;Kramer, Arthur F.
通讯作者：
Kramer, Arthur F.
影响因子：
8.3
作者：
Holland, Christopher M.;Smith, Eric E.;Greenberg, Steven M.
通讯作者：
Greenberg, Steven M.