Dynamic, but Not Necessarily Disordered, Human-Virus Interactions Mediated through SLiMs in Viral Proteins.
Dynamic, but Not Necessarily Disordered, Human-Virus Interactions Mediated through SLiMs in Viral Proteins.
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DOI：
10.3390/v13122369
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发表时间：
2021-11-26
期刊：
影响因子：
--
通讯作者：
Siltberg-Liberles J
中科院分区：
文献类型：
--
作者：
Elkhaligy H;Balbin CA;Gonzalez JL;Liberatore T;Siltberg-Liberles J
大多数病毒都有很小的基因组，编码执行基本酶功能所需的蛋白质。在整个病毒家族中，主要的酶功能受到功能的限制；然而，由暴露的蛋白表面介导的促进与宿主蛋白相互作用的次要功能可能受到较少的限制。病毒通常通过构象灵活的界面与宿主蛋白形成瞬时相互作用。已知暴露的柔性氨基酸残基进化迅速，这表明二级功能可能在同一病毒家族中的病毒之间产生不同的相互作用潜力。相互作用的一种机制是通过作为宿主蛋白功能签名的短线性基序(SLIMs)进行病毒模仿。病毒苗条显示出与宿主苗条相似的相邻氨基酸的特定模式，由于突变和选择性过程，病毒蛋白中可能会偶然出现多次。通过模仿宿主细胞蛋白质组中的纤细，病毒可以干扰宿主的蛋白质相互作用网络，并利用宿主细胞机制对它们有利。快速进化的蛋白质区域和功能关键纤细的位置之间的重叠表明，这些基序及其功能潜力可能被快速重新连接，导致相关病毒的致病性、感染性和毒力的变化。下面的综述概述了已知的病毒纤细及其在病毒生命周期中的作用的精选实例，并讨论了经实验验证的纤细的结构特性，强调了很大一部分已知的病毒纤细缺乏基于ELM数据库中的病毒纤细而预测的内在疾病。
Most viruses have small genomes that encode proteins needed to perform essential enzymatic functions. Across virus families, primary enzyme functions are under functional constraint; however, secondary functions mediated by exposed protein surfaces that promote interactions with the host proteins may be less constrained. Viruses often form transient interactions with host proteins through conformationally flexible interfaces. Exposed flexible amino acid residues are known to evolve rapidly suggesting that secondary functions may generate diverse interaction potentials between viruses within the same viral family. One mechanism of interaction is viral mimicry through short linear motifs (SLiMs) that act as functional signatures in host proteins. Viral SLiMs display specific patterns of adjacent amino acids that resemble their host SLiMs and may occur by chance numerous times in viral proteins due to mutational and selective processes. Through mimicry of SLiMs in the host cell proteome, viruses can interfere with the protein interaction network of the host and utilize the host-cell machinery to their benefit. The overlap between rapidly evolving protein regions and the location of functionally critical SLiMs suggest that these motifs and their functional potential may be rapidly rewired causing variation in pathogenicity, infectivity, and virulence of related viruses. The following review provides an overview of known viral SLiMs with select examples of their role in the life cycle of a virus, and a discussion of the structural properties of experimentally validated SLiMs highlighting that a large portion of known viral SLiMs are devoid of predicted intrinsic disorder based on the viral SLiMs from the ELM database.
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影响因子：
5.4
作者：
Aoki, H;Hayashi, J;Hino, O
通讯作者：
Hino, O
影响因子：
4.8
作者：
Cristea, Ileana M.;Carroll, John-William N.;MacDonald, Margaret R.
通讯作者：
MacDonald, Margaret R.
影响因子：
5.4
作者：
Cui, Jie;Schlub, Timothy E.;Holmes, Edward C.
通讯作者：
Holmes, Edward C.
DOI：
10.1073/pnas.0907508106
发表时间：
2009-12-01
影响因子：
11.1
作者：
Chesnokova, Liudmila S.;Nishimura, Stephen L.;Hutt-Fletcher, Lindsey M.
通讯作者：
Hutt-Fletcher, Lindsey M.
影响因子：
5.6
作者：
Charbonnier, Sebastian;Nomine, Yves;Atkinson, R. Andrew
通讯作者：
Atkinson, R. Andrew