A pictorial account of the human embryonic heart between 3.5 and 8 weeks of development.
A pictorial account of the human embryonic heart between 3.5 and 8 weeks of development.
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DOI：
10.1038/s42003-022-03153-x
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发表时间：
2022-03-11
影响因子：
5.9
通讯作者：
Lamers WH
中科院分区：
文献类型：
--
作者：
Hikspoors JPJM;Kruepunga N;Mommen GMC;Köhler SE;Anderson RH;Lamers WH
心脏发育在地形上是复杂的，需要可视化来了解其进展。目前还没有全面的人类心脏发育的三维引物。我们使用Amira® 3D重建和Cinema 4D ®重建软件，在受精后3.5至8周之间对12个心脏进行了详细的重建。这些模型被可视化为校准的交互式3D-PDF。我们描述的发展外观和随后的重塑70个不同的结构增量，使用顺序节段分析。结构的图示时间线突出了年龄依赖性事件，而图表可视化了心管壁的生长和螺旋。在3.5至4.5周之间建立基本的心脏布局。6周时完成静脉极的分隔。5.5 ~ 6.5周时，随着流出道并入心室，其主动脉下和肺动脉下通道的螺旋形行程转移到心包内动脉干。室间孔的重塑在7周时完成。Hikspoors等人绘制了3.5至8周人类胚胎心脏发育的图片。该资源提供详细的交互式3D解剖模型，并量化心脏功能关键结构的发育里程碑。
Heart development is topographically complex and requires visualization to understand its progression. No comprehensive 3-dimensional primer of human cardiac development is currently available. We prepared detailed reconstructions of 12 hearts between 3.5 and 8 weeks post fertilization, using Amira® 3D-reconstruction and Cinema4D®-remodeling software. The models were visualized as calibrated interactive 3D-PDFs. We describe the developmental appearance and subsequent remodeling of 70 different structures incrementally, using sequential segmental analysis. Pictorial timelines of structures highlight age-dependent events, while graphs visualize growth and spiraling of the wall of the heart tube. The basic cardiac layout is established between 3.5 and 4.5 weeks. Septation at the venous pole is completed at 6 weeks. Between 5.5 and 6.5 weeks, as the outflow tract becomes incorporated in the ventricles, the spiraling course of its subaortic and subpulmonary channels is transferred to the intrapericardial arterial trunks. The remodeling of the interventricular foramen is complete at 7 weeks. Hikspoors et al. generate a pictorial account of human embryonic heart development between 3.5 and 8 weeks. This resource provides detailed, interactive 3D anatomical models and quantifies the developmental milestones of key structures in cardiac function.
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影响因子：
2.5
作者：
Chen, Fuhua;De Diego, Carlos;Chang, Marvin G.;McHarg, Jennifer L.;John, Scott;Klitzner, Thomas S.;Weiss, James N.
通讯作者：
Weiss, James N.
DOI：
10.1002/ar.24020
发表时间：
2019-01-01
影响因子：
2
作者：
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作者：
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通讯作者：
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