Lymphatic lipid transport: sewer or subway?

Lymphatic lipid transport: sewer or subway?
复制标题

DOI:
10.1016/j.tem.2010.04.003
复制
发表时间:
2010-08
影响因子:
10.9
通讯作者:
Dixon, J. Brandon
Dixon, J. Brandon
中科院分区:
医学1区
文献类型:
--
作者:
Dixon, J. Brandon

文献摘要

参考文献

被引文献

相似文献

早在 1622 年,淋巴管就开始受到科学界的关注,当时加斯帕罗·阿塞利 (Gasparo Aselli) 注意到一只喂养良好的狗的肠系膜中出现了乳白色血管。从那时起,淋巴系统历来被视为脉管系统的下水道,被动地将液体和蛋白质从组织间隙(以及来自肠道的脂质)排入血液。然而,最近的报告表明,淋巴在脂质运输中的作用是一个活跃且复杂的过程,当淋巴功能受损时,会对脂质代谢和运输产生系统性影响。这篇综述强调了这些最新发现,并提出了了解健康和疾病中淋巴和脂质生物学之间相互作用的未来方向。
The lymphatics began receiving attention in the scientific community as early as 1622, when Gasparo Aselli noted the appearance of milky white vessels in the mesentery of a well-fed dog. Since this time, the lymphatic system has been historically regarded as the sewer of the vasculature, passively draining fluid and proteins from the interstitial spaces (along with lipid from the gut) into the blood. Recent reports, however, suggest that the lymphatic role in lipid transport is an active and intricate process and when lymphatic function is compromised, there are systemic consequences to lipid metabolism and transport. This review highlights these recent findings and suggests future directions for understanding the interplay between lymphatic and lipid biology in health and disease.
DOI: 10.1016/j.devcel.2009.06.017
发表时间: 2009-08
期刊: DEVELOPMENTAL CELL
影响因子: 11.8
作者:
Bazigou, Eleni;Xie, Sherry;Chen, Chun;Weston, Anne;Miura, Naoyuki;Sorokin, Lydia;Adams, Ralf;Muro, Andres F.;Sheppard, Dean;Makinen, Taija
通讯作者: Makinen, Taija
DOI: 10.1002/cyto.a.20587
发表时间: 2008-10
期刊: CYTOMETRY PART A
影响因子: 3.7
作者:
Galanzha, Ekaterina I.;Shashkov, Evgeny V.;Tuchin, Valery V.;Zharov, Vladimir P.
通讯作者: Zharov, Vladimir P.
DOI: 10.1016/j.immuni.2004.09.003
发表时间: 2004-10-01
期刊: IMMUNITY
影响因子: 32.4
作者:
Angeli, V;Llodrá, J;Randolph, GJ
通讯作者: Randolph, GJ
DOI: 10.1038/21224
发表时间: 1999-06-10
期刊: NATURE
影响因子: 64.8
作者:
Dimmeler, S;Fleming, I;Zeiher, AM
通讯作者: Zeiher, AM
DOI: 10.1117/1.2135791
发表时间: 2005-11-01
影响因子: 3.5
作者:
Dixon, JB;Zawieja, DC;Coté, GL
通讯作者: Coté, GL