Circular RNA expression profiles significantly altered in UVA-irradiated human dermal fibroblasts.
Circular RNA expression profiles significantly altered in UVA-irradiated human dermal fibroblasts.
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UVA 照射的人真皮成纤维细胞中的环状 RNA 表达谱显着改变
DOI：
10.3892/etm.2020.9292
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发表时间：
2020-12
影响因子：
2.7
通讯作者：
Lai W
中科院分区：
文献类型：
--
作者：
Lin M;Zheng Y;Li Q;Liu Y;Xu Q;Li Y;Lai W
环状RNA（circRNA）先前已经与许多疾病有关。然而，circRNA在光老化中的作用仍然难以捉摸。在本研究中，为了了解光老化是否影响circRNA表达水平，对紫外线A（UVA）照射的人真皮成纤维细胞中circRNA的表达进行了分析。在UVA暴露后，总共鉴定出128个circRNA差异表达（倍数变化>1.5; P<0.05），包括39个上调和89个下调的circRNA。Gene Ontology和京都基因百科全书和基因组生物学途径分析表明差异表达的circRNA与细胞外基质组织和代谢有关。本研究揭示了UVA照射后人皮肤成纤维细胞中circRNA表达模式的改变。这些结果不仅为深入研究皮肤光老化机制提供了依据，而且为预防和治疗光老化及其相关皮肤病提供了新的可能。
Circular RNAs (circRNAs) have been previously implicated in number of diseases. However, the roles of circRNAs in photoaging remain elusive. In the present study, to understand if photoaging influences the levels of circRNA expression, the expression of circRNAs in ultraviolet A (UVA)-irradiated human dermal fibroblasts were profiled. A total of 128 circRNAs were identified to be differentially expressed (fold change >1.5; P<0.05) after UVA exposure, including 39 upregulated and 89 downregulated circRNAs. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes biological pathway analyses indicated that the differentially expressed circRNAs were associated with extracellular matrix organization and metabolism. The present study revealed an altered circRNA expression pattern in human dermal fibroblasts following UVA-irradiation. These results provide not only a basis for in-depth study of the mechanism of skin photoaging but also a new possibility for the prevention and treatment of photoaging and associated skin diseases.
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影响因子：
14.9
作者：
Ritchie ME;Phipson B;Wu D;Hu Y;Law CW;Shi W;Smyth GK
通讯作者：
Smyth GK
影响因子：
3.7
作者：
Wheatley AK;Kramski M;Alexander MR;Toe JG;Center RJ;Purcell DF
通讯作者：
Purcell DF
circCOL3A1-859267 通过海绵 miR-29c 在人真皮成纤维细胞中调节 I 型胶原表达
影响因子：
2.5
作者：
Peng, Yating;Song, Xiaojing;Lai, Wei
通讯作者：
Lai, Wei
DOI：
10.1038/skinbio.2013.176
发表时间：
2013-07-01
期刊：
The Journal of investigative dermatology
影响因子：
--
作者：
Gilchrest, Barbara A
通讯作者：
Gilchrest, Barbara A
影响因子：
5.2
作者：
Li, Mengna;Li, Li;Yan, Yan
通讯作者：
Yan, Yan