Recent advances in crosstalk between N6-methyladenosine (m6A) modification and circular RNAs in cancer.
Recent advances in crosstalk between N6-methyladenosine (m6A) modification and circular RNAs in cancer.
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DOI：
10.1016/j.omtn.2022.01.013
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发表时间：
2022-03-08
期刊：
影响因子：
--
通讯作者：
Zhang W
中科院分区：
文献类型：
--
作者：
Huang X;Guo H;Wang L;Yang L;Shao Z;Zhang W
N6-甲基腺苷(M6A)作为最常见的RNA修饰，在肿瘤的发生发展中起着至关重要的作用。环状RNA(CircRNAs)是一类单链共价闭合的RNA分子。最近，M6A修饰被发现具有调节CircRNAs的生物学功能。越来越多的证据还表明，CircRNAs通过靶向m6A调节因子参与癌症的进展。在这篇综述中，我们描述了m6A和CircRNAs之间的功能串扰，并阐明了它们在癌症发展中的作用。在不同的癌症类型中，M6A甲基化介导了CircRNAs的生物发生、稳定性和胞浆输出。此外，CircRNAs调控m6A调节子的表达，参与m6A调节子的降解，并调控靶mRNAs的m6A修饰。最后，讨论了M6A修饰和CircRNAs在肿瘤中的潜在应用和未来的研究方向。进一步了解M6A和CircRNAs的生物学作用将为癌症患者的诊断和治疗提供新的见解。在这篇综述中，我们描述了N6-甲基腺苷(M6A)和环状RNA(CircRNAs)之间的功能串扰，并阐明了它们在癌症发展中的作用。进一步了解M6A和CircRNAs的生物学作用将为癌症患者的诊断和治疗提供新的见解。
N6-methyladenosine (m6A), as the most common RNA modification, plays a vital role in the development of cancers. Circular RNAs (circRNAs) are a class of single-stranded covalently closed RNA molecules. Recently, m6A modification has been identified as performing biological functions for regulating circRNAs. Increasing evidence also shows that circRNAs are involved in cancer progression by targeting m6A regulators. In this review, we describe the functional crosstalk between m6A and circRNAs, and illustrate their roles in cancer development. m6A methylation mediates the biogenesis, stability, and cytoplasmic export of circRNAs in different cancer types. Moreover, circRNAs regulate the expression of m6A regulators, participate in the degradation of m6A regulators, and regulate the m6A modification of target mRNAs. Finally, we discuss the potential applications and future research directions of m6A modification and circRNAs in cancer. Further understanding of the biological roles of m6A and circRNAs will provide new insight into the diagnosis and treatment of cancer patients. In this review, we describe the functional crosstalk between N6-methyladenosine (m6A) and circular RNAs (circRNAs), and illustrate their roles in cancer development. Further understanding of the biological roles of m6A and circRNAs will provide new insight into the diagnosis and treatment of cancer patients.
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