Immunosuppressive and non-immunosuppressive immunophilin ligands improve H2O2-induced cell damage by increasing glutathione levels in NG108-15 cells
Immunosuppressive and non-immunosuppressive immunophilin ligands improve H2O2-induced cell damage by increasing glutathione levels in NG108-15 cells
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免疫抑制和非免疫抑制亲免素配体通过增加 NG108-15 细胞中谷胱甘肽水平来改善 H2O2 诱导的细胞损伤
DOI：
10.1016/s0006-8993(00)02851-1
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发表时间：
2001
期刊：
影响因子：
2.9
通讯作者：
N. Ogawa
中科院分区：
文献类型：
--
作者：
Ken;N. Fujita;Michiyo Yoshioka;N. Ogawa
我们研究了FK 506及其非免疫抑制衍生物GPI 1046对NG 108-15细胞中H2 O2诱导的氧化性细胞损伤的影响。我们的研究结果表明，GPI 1046的保护性能与FK 506的保护性能是等效的，并且可能通过增加细胞内谷胱甘肽（GSH）浓度来介导。因此，非免疫抑制性亲免素配体如GPI 1046可能潜在地用于神经退行性疾病，特别是因为它们没有严重的副作用如免疫缺陷。
We examined the effects of FK506 and its non-immunosuppressive derivative, GPI1046, on H2O2-induced oxidative cell damage in NG 108-15 cells. Our results suggest that the protective properties of GPI1046 are equipotent with those of FK506 and may be mediated by increased intracellular concentrations of glutathione (GSH). Thus, non-immunosuppressive immunophilin ligands such as GPI1046 might be potentially for neurodegenerative diseases, particularly since they do not have serious side effects such as immune deficiency.
亲免素配体的神经作用。
影响因子：
13.8
作者：
Snyder,SH;Sabatini,DM;Lai,MM;Steiner,JP;Hamilton,GS;Suzdak,PD
通讯作者：
Suzdak,PD
DOI：
10.1073/pnas.91.8.3191
发表时间：
1994-04-12
影响因子：
11.1
作者：
LYONS, WE;GEORGE, EB;SNYDER, SH
通讯作者：
SNYDER, SH