Autophagy in kidney homeostasis and disease.
Autophagy in kidney homeostasis and disease.
复制标题
自噬在肾脏稳态和疾病中的作用
DOI：
10.1038/s41581-020-0309-2
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发表时间：
2020-09
期刊：
影响因子：
--
通讯作者：
Dong Z
中科院分区：
文献类型：
--
作者：
Tang C;Livingston MJ;Liu Z;Dong Z
自噬是一种保守的溶酶体降解细胞质成分的途径。肾细胞中的基础自噬对于维持肾的稳态、结构和功能是必不可少的。在应激条件下，自噬作为肾细胞适应性反应的一部分而改变，该过程受到可以调节细胞自噬通量的信号传导途径的严格调节-雷帕霉素的哺乳动物靶标、AMP活化的蛋白激酶和沉默调节蛋白是自噬的关键调节剂。失调的自噬导致急性肾损伤的发病机制、急性肾损伤后的不完全肾修复以及各种病因的慢性肾病，包括糖尿病肾病、局灶节段性肾小球硬化症和多囊肾病。自噬也在肾脏衰老中发挥作用。然而，关于自噬在肾纤维化中是否具有保护作用或病理作用，以及不同类型肾细胞和肾脏疾病谱中自噬反应的确切机制和信号通路仍然存在疑问。需要进一步的研究来深入了解肾脏中自噬的调节，并能够发现肾脏疾病和抗衰老策略的途径特异性和肾脏选择性疗法。
Autophagy is a conserved lysosomal pathway for the degradation of cytoplasmic components. Basal autophagy in kidney cells is essential for the maintenance of kidney homeostasis, structure and function. Under stress conditions, autophagy is altered as part of the adaptive response of kidney cells, in a process that is tightly regulated by signalling pathways that can modulate the cellular autophagic flux — mammalian target of rapamycin, AMP-activated protein kinase and sirtuins are key regulators of autophagy. Dysregulated autophagy contributes to the pathogenesis of acute kidney injury, to incomplete kidney repair after acute kidney injury and to chronic kidney disease of varied aetiologies, including diabetic kidney disease, focal segmental glomerulosclerosis and polycystic kidney disease. Autophagy also has a role in kidney ageing. However, questions remain about whether autophagy has a protective or a pathological role in kidney fibrosis, and about the precise mechanisms and signalling pathways underlying the autophagy response in different types of kidney cells and across the spectrum of kidney diseases. Further research is needed to gain insights into the regulation of autophagy in the kidneys and to enable the discovery of pathway-specific and kidney-selective therapies for kidney diseases and anti-ageing strategies.
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影响因子：
13.3
作者：
Chang K;Kang P;Liu Y;Huang K;Miao T;Sagona AP;Nezis IP;Bodmer R;Ocorr K;Bai H
通讯作者：
Bai H
影响因子：
13.5
作者：
Dai H;Sinclair DA;Ellis JL;Steegborn C
通讯作者：
Steegborn C
Optineurin介导的线粒体自噬保护糖尿病肾病肾小管上皮细胞免于加速衰老
影响因子：
9
作者：
Chen K;Dai H;Yuan J;Chen J;Lin L;Zhang W;Wang L;Zhang J;Li K;He Y
通讯作者：
He Y
DOI：
10.1152/ajprenal.00255.2017
发表时间：
2017-09-01
影响因子：
4.2
作者：
Chuang, Peter Y.;Cai, Weijing;Lee, Kyung
通讯作者：
Lee, Kyung
影响因子：
82.9
作者：
Beckerman P;Bi-Karchin J;Park AS;Qiu C;Dummer PD;Soomro I;Boustany-Kari CM;Pullen SS;Miner JH;Hu CA;Rohacs T;Inoue K;Ishibe S;Saleem MA;Palmer MB;Cuervo AM;Kopp JB;Susztak K
通讯作者：
Susztak K