Neural representation of orientation relative to gravity in the macaque cerebellum.

Neural representation of orientation relative to gravity in the macaque cerebellum.
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DOI:
10.1016/j.neuron.2013.09.029
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发表时间:
2013-12-18
期刊:
影响因子:
16.2
通讯作者:
Angelaki DE
Angelaki DE
中科院分区:
医学1区
文献类型:
--
作者:
Laurens J;Meng H;Angelaki DE

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保持空间方向和与世界互动的一个基本挑战是我们相对于重力的方向知识,即倾斜。由于爱因斯坦的等效原理,引力和平移加速度在物理上是不可区分的,因此感知引力是复杂的。理论上提出,通过多感觉整合跟踪头部倾斜来解决这种模糊性。在这里,我们确定了一组浦肯野细胞在小脑尾蚓部的反应,反映了头部倾斜的估计。这些倾斜选择性细胞是互补的选择性浦肯野细胞,使他们的人口活动总和的净重力惯性加速度编码的耳石器官,如理论所预测的。这些发现反映了小脑神经计算的非凡能力,并为重力的神经表示提供了新的定量证据,其计算依赖于长期假设的理论概念,如内部模型和贝叶斯先验。
A fundamental challenge for maintaining spatial orientation and interacting with the world is knowledge of our orientation relative to gravity, i.e. tilt. Sensing gravity is complicated because of Einstein’s equivalence principle, where gravitational and translational accelerations are physically indistinguishable. Theory has proposed that this ambiguity is solved by tracking head tilt through multisensory integration. Here we identify a group of Purkinje cells in the caudal cerebellar vermis with responses that reflect an estimate of head tilt. These tilt-selective cells are complementary to translation-selective Purkinje cells, such that their population activities sum to the net gravito-inertial acceleration encoded by the otolith organs, as predicted by theory. These findings reflect the remarkable ability of the cerebellum for neural computation and provide novel quantitative evidence for a neural representation of gravity, whose calculation relies on long-postulated theoretical concepts such as internal models and Bayesian priors.
DOI: 10.1523/jneurosci.1607-09.2009
发表时间: 2009-07-15
期刊: The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子: --
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