Neural representation of orientation relative to gravity in the macaque cerebellum.
Neural representation of orientation relative to gravity in the macaque cerebellum.
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DOI:
10.1016/j.neuron.2013.09.029
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发表时间:
2013-12-18
期刊:
影响因子:
16.2
通讯作者:
Angelaki DE
中科院分区:
文献类型:
--
作者:
Laurens J;Meng H;Angelaki DE
A fundamental challenge for maintaining spatial orientation and interacting with the world is knowledge of our orientation relative to gravity, i.e. tilt. Sensing gravity is complicated because of Einstein’s equivalence principle, where gravitational and translational accelerations are physically indistinguishable. Theory has proposed that this ambiguity is solved by tracking head tilt through multisensory integration. Here we identify a group of Purkinje cells in the caudal cerebellar vermis with responses that reflect an estimate of head tilt. These tilt-selective cells are complementary to translation-selective Purkinje cells, such that their population activities sum to the net gravito-inertial acceleration encoded by the otolith organs, as predicted by theory. These findings reflect the remarkable ability of the cerebellum for neural computation and provide novel quantitative evidence for a neural representation of gravity, whose calculation relies on long-postulated theoretical concepts such as internal models and Bayesian priors.
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DOI:
10.1523/jneurosci.1607-09.2009
发表时间:
2009-07-15
期刊:
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子:
--
作者:
Liu S;Angelaki DE
通讯作者:
Angelaki DE
影响因子:
2
作者:
MacNeilage, Paul R.;Banks, Martin S.;Buelthoff, Heinrich H.
通讯作者:
Buelthoff, Heinrich H.
影响因子:
4.6
作者:
ANGELAKI, DE
通讯作者:
ANGELAKI, DE
影响因子:
1.9
作者:
Bos, JE;Bles, W
通讯作者:
Bles, W
影响因子:
3.8
作者:
Curthoys, IS
通讯作者:
Curthoys, IS