Incorporating Tumor-Associated Macrophages into Engineered Models of Glioma.
Incorporating Tumor-Associated Macrophages into Engineered Models of Glioma.
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DOI：
10.1016/j.isci.2020.101770
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发表时间：
2020-12-18
期刊：
影响因子：
5.8
通讯作者：
Kumar S
中科院分区：
文献类型：
--
作者：
Akins EA;Aghi MK;Kumar S
肿瘤进展受到癌细胞和肿瘤微环境（TME）之间相互作用的深刻影响。在存在的各种非肿瘤细胞中，免疫细胞是肿瘤发展的关键参与者，因此已成为有吸引力的治疗靶点。恶性胶质瘤表现出独特的免疫景观，其特征在于大量的肿瘤相关巨噬细胞（TAM）。尽管临床前结果令人鼓舞，但靶向TAM作为减缓胶质瘤进展的策略取得了有限的临床成功。TAM靶向治疗的缓慢转化进展部分是由于对驱动TAM募集、分化和极化的因素的不完全理解。此外，TAM在神经胶质瘤中的功能在很大程度上仍然未知。在解决这些差距方面的进展需要能够捕获关键细胞和物理TME特征的复杂培养平台。这篇综述总结了目前对TAM在胶质瘤中的认识，并强调了体外TME模型用于研究TAM-癌细胞串扰的实用性。免疫学;生物工程;癌症
Tumor progression is profoundly influenced by interactions between cancer cells and the tumor microenvironment (TME). Among the various non-neoplastic cells present, immune cells are critical players in tumor development and have thus emerged as attractive therapeutic targets. Malignant gliomas exhibit a unique immune landscape characterized by high numbers of tumor-associated macrophages (TAMs). Despite encouraging preclinical results, targeting TAMs has yielded limited clinical success as a strategy for slowing glioma progression. The slow translational progress of TAM-targeted therapies is due in part to an incomplete understanding of the factors driving TAM recruitment, differentiation, and polarization. Furthermore, the functions that TAMs adopt in gliomas remain largely unknown. Progress in addressing these gaps requires sophisticated culture platforms capable of capturing key cellular and physical TME features. This review summarizes the current understanding of TAMs in gliomas and highlights the utility of in vitro TME models for investigating TAM-cancer cell cross talk. Immunology; Bioengineering; Cancer
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