Impaired fasting glucose: a risk factor for atrial fibrillation and heart failure.
Impaired fasting glucose: a risk factor for atrial fibrillation and heart failure.
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DOI：
10.1186/s12933-021-01422-3
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发表时间：
2021-11-24
影响因子：
9.3
通讯作者：
Norhammar A
中科院分区：
文献类型：
--
作者：
Lind V;Hammar N;Lundman P;Friberg L;Talbäck M;Walldius G;Norhammar A
即使在糖尿病前期水平，血脂异常也与总体心血管疾病相关。本研究的目的是分别探讨血糖水平与未来发生房颤和心力衰竭风险之间的关系。在这项前瞻性队列研究中，对来自瑞典AMORIS队列的受试者（1985-1996年健康检查空腹血糖，既往无心血管疾病）（N = 294，057）进行了随访，直至2011年12月31日发生房颤或心力衰竭。使用考克斯比例风险模型，以达到的年龄作为时间尺度，并对性别、胆固醇、甘油三酯和社会经济状况进行校正，以估计血糖分类组的风险比（正常血糖3.9-6.0 mmol/L，空腹血糖受损6.1-6.9 mmol/L，未诊断的糖尿病≥ 7.0 mmol/L，和诊断的糖尿病）。在平均19.1年的随访时间内，28，233人发生房颤，25，604人发生心力衰竭。空腹血糖受损组房颤的HR为1.19（95%置信区间1.13-1.26），未确诊糖尿病组为1.23（1.15-1.32），确诊糖尿病组为1.30（1.21-1.41）。心力衰竭的相应数字分别为：1.40（1.33-1.48）、2.11（1.99-2.23）、2.22（2.08-2.36）。在一个有BMI数据的子集（19%）中，这些相关性减弱，仅在确诊为糖尿病的受试者中，房颤的相关性保持统计学显著性（HR 1.25; 1.02-1.53）。空腹血糖处于糖尿病前期水平与房颤和心力衰竭的发生有关。在某种程度上，BMI的增加可能会推动这种关联。在线版本包含补充材料，可通过10.1186/s12933-021-01422-3获得。
Dysglycaemia is associated with overall cardiovascular disease even at prediabetes levels. The aim of this study was to explore the association between glucose levels and future risk of developing atrial fibrillation and heart failure, respectively. In this prospective cohort study subjects from the Swedish AMORIS-cohort with fasting glucose from health examinations 1985–1996 without previous cardiovascular disease (N = 294,057) were followed to 31 December 2011 for incident atrial fibrillation or heart failure. Cox proportional hazard models with attained age as timescale and adjustments for sex, cholesterol, triglycerides, and socioeconomic status were used to estimate hazard ratios by glucose categorized groups (normal glucose 3.9–6.0 mmol/L, impaired fasting glucose; 6.1–6.9 mmol/L, undiagnosed diabetes ≥ 7.0 mmol/L, and diagnosed diabetes). During a mean follow-up time of 19.1 years 28,233 individuals developed atrial fibrillation and 25,604 developed heart failure. The HR for atrial fibrillation was 1.19 (95% confidence interval 1.13–1.26) for impaired fasting glucose, 1.23 (1.15–1.32) for undiagnosed diabetes and 1.30 (1.21–1.41) for diagnosed diabetes. Corresponding figures for heart failure were; 1.40 (1.33–1.48), 2.11 (1.99–2.23), 2.22 (2.08–2.36) respectively. In a subset with BMI data (19%), these associations were attenuated and for atrial fibrillation only remained statistically significant among subjects with diagnosed diabetes (HR 1.25; 1.02–1.53). Fasting glucose at prediabetes levels is associated with development of atrial fibrillation and heart failure. To some extent increased BMI may drive this association. The online version contains supplementary material available at 10.1186/s12933-021-01422-3.
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影响因子：
37.8
作者：
Huxley RR;Lopez FL;Folsom AR;Agarwal SK;Loehr LR;Soliman EZ;Maclehose R;Konety S;Alonso A
通讯作者：
Alonso A
影响因子：
8.2
作者：
Norhammar, Anna;Bodegard, Johan;Nathanson, David
通讯作者：
Nathanson, David
影响因子：
7
作者：
Donnellan, Eoin;Aagaard, Philip;Wazni, Oussama
通讯作者：
Wazni, Oussama
影响因子：
24
作者：
Pathak, Rajeev K.;Middeldorp, Melissa E.;Sanders, Prashanthan
通讯作者：
Sanders, Prashanthan
影响因子：
120.7
作者：
BENJAMIN, EJ;LEVY, D;WOLF, PA
通讯作者：
WOLF, PA