Microparticles: biogenesis, characteristics and intervention therapy for cancers in preclinical and clinical research.
Microparticles: biogenesis, characteristics and intervention therapy for cancers in preclinical and clinical research.
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微粒：临床前和临床研究中癌症的生物发生、特征和干预治疗
DOI：
10.1186/s12951-022-01358-0
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发表时间：
2022-04-13
影响因子：
10.2
通讯作者：
Yang, Kunyu
中科院分区：
文献类型：
--
作者：
Hu, Yan;Sun, Yajie;Wan, Chao;Dai, Xiaomeng;Wu, Shuhui;Lo, Pui-Chi;Huang, Jing;Lovell, Jonathan F.;Jin, Honglin;Yang, Kunyu
Extracellular vesicles (EVs), spherical biological vesicles, mainly contain nucleic acids, proteins, lipids and metabolites for biological information transfer between cells. Microparticles (MPs), a subtype of EVs, directly emerge from plasma membranes, and have gained interest in recent years. Specific cell stimulation conditions, such as ultraviolet and X-rays irradiation, can induce the release of MPs, which are endowed with unique antitumor functionalities, either for therapeutic vaccines or as direct antitumor agents. Moreover, the size of MPs (100–1000 nm) and their spherical structures surrounded by a lipid bilayer membrane allow MPs to function as delivery vectors for bioactive antitumor compounds, with favorable phamacokinetic behavior, immunostimulatory activity and biological function, without inherent carrier-specific toxic side effects. In this review, the mechanisms underlying MP biogenesis, factors that influence MP production, properties of MP membranes, size, composition and isolation methods of MPs are discussed. Additionally, the applications and mechanisms of action of MPs, as well as the main hurdles for their applications in cancer management, are introduced.
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影响因子：
2.4
作者：
Bordeleau F;Chan B;Antonyak MA;Lampi MC;Cerione RA;Reinhart-King CA
通讯作者：
Reinhart-King CA
DOI：
10.1038/nrmicro1927
发表时间：
2008-07
期刊：
Nature reviews. Microbiology
影响因子：
--
作者：
通讯作者：
--
影响因子：
3.7
作者：
Chauhan, Vinita S.;Furr, Samantha R.;Grdzelishvili, Valery Z.
通讯作者：
Grdzelishvili, Valery Z.
影响因子：
19.7
作者：
Al Faraj, Achraf;Gazeau, Florence;Rautou, Pierre-Emmanuel
通讯作者：
Rautou, Pierre-Emmanuel
影响因子：
7.2
作者：
Berchem G;Noman MZ;Bosseler M;Paggetti J;Baconnais S;Le Cam E;Nanbakhsh A;Moussay E;Mami-Chouaib F;Janji B;Chouaib S
通讯作者：
Chouaib S