Hypoxia, stem cells and bone tumor.
Hypoxia, stem cells and bone tumor.
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DOI:
10.1016/j.canlet.2011.09.023
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发表时间:
2011-12-27
期刊:
影响因子:
9.7
通讯作者:
Wei, Yiyong
中科院分区:
文献类型:
--
作者:
Zeng, Wen;Wan, Rong;Zheng, Yuehuan;Singh, Shree Ram;Wei, Yiyong
Normal oxygen level is critical for niches that together with other components of the niche play vital role in regulating stem or tumor cells behavior. Hypoxia plays an important role in normal development and disease progression, including the growth of solid tumors. The hypoxia inducible factors (HIFs) are the key mediators of the cellular response to hypoxia. In this review, we focused on the role of HIFs on bone tumor formation. Further, we also emphasized how hypoxia, stem cells, and its niches regulate the bone tumorigenesis.
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