Age-dependent gene expression in the inner ear of big brown bats (Eptesicus fuscus).
Age-dependent gene expression in the inner ear of big brown bats (Eptesicus fuscus).
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DOI：
10.1371/journal.pone.0186667
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Wilkinson GS
中科院分区：
文献类型：
--
作者：
Mao B;Moss CF;Wilkinson GS
对于回声定位蝙蝠来说，听力是生存的关键。在他们的听觉系统中，检测和处理高频声音的专门化是显而易见的。最近关于回声定位哺乳动物的研究报道了一些与听力相关的基因平行进化的证据，在这些基因中，回声定位动物(蝙蝠和齿鲸)的远亲群体由于明显的氨基酸聚合而聚集在基因树中。然而，分子适应不仅可以发生在编码序列中，也可以发生在基因表达的调节中。本研究的目的是研究在回声定位发声频率急剧增加的时期，发育中的大棕色蝙蝠(Eptesicus Fuscus)内耳中与听力相关的基因的表达。我们发现，有7个基因在青少年中相对于成年显著上调，并且4个基因在发育过程中的表达与估计的年龄相关。与小鼠的现有数据相比，一些听力基因在幼年蝙蝠中的表达似乎延长了。这些结果与回声定位蝙蝠发育更大的耳蜗所需的较长的生长期一致，高频听力的成熟较晚，以及对高频听力的更大依赖。
For echolocating bats, hearing is essential for survival. Specializations for detecting and processing high frequency sounds are apparent throughout their auditory systems. Recent studies on echolocating mammals have reported evidence of parallel evolution in some hearing-related genes in which distantly related groups of echolocating animals (bats and toothed whales), cluster together in gene trees due to apparent amino acid convergence. However, molecular adaptations can occur not only in coding sequences, but also in the regulation of gene expression. The aim of this study was to examine the expression of hearing-related genes in the inner ear of developing big brown bats, Eptesicus fuscus, during the period in which echolocation vocalizations increase dramatically in frequency. We found that seven genes were significantly upregulated in juveniles relative to adults, and that the expression of four genes through development correlated with estimated age. Compared to available data for mice, it appears that expression of some hearing genes is extended in juvenile bats. These results are consistent with a prolonged growth period required to develop larger cochlea relative to body size, a later maturation of high frequency hearing, and a greater dependence on high frequency hearing in echolocating bats.
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影响因子：
2.3
作者：
BUCHLER, ER
通讯作者：
BUCHLER, ER
影响因子：
56.9
作者：
DEKOK, YJM;VANDERMAAREL, SM;CREMERS, FPM
通讯作者：
CREMERS, FPM
影响因子：
56.9
作者：
Bates, Mary E.;Simmons, James A.;Zorikov, Tengiz V.
通讯作者：
Zorikov, Tengiz V.
影响因子：
64.8
作者：
ECHTELER, SM;ARJMAND, E;DALLOS, P
通讯作者：
DALLOS, P
DOI：
10.1007/bf00611192
发表时间：
1983-01-01
期刊：
JOURNAL OF COMPARATIVE PHYSIOLOGY
影响因子：
--
作者：
HABERSETZER, J;VOGLER, B
通讯作者：
VOGLER, B