Manipulation of cellular redox parameters for improving therapeutic responses in B-cell lymphoma and multiple myeloma.
Manipulation of cellular redox parameters for improving therapeutic responses in B-cell lymphoma and multiple myeloma.
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DOI：
10.1002/jcb.23387
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发表时间：
2012-02
影响因子：
4
通讯作者：
Weiner, George J.
中科院分区：
文献类型：
--
作者：
Goel, Apollina;Spitz, Douglas R.;Weiner, George J.
在了解氧化还原生物学参与恶性细胞凋亡的基础上，发展新的综合治疗方法是提高B细胞淋巴瘤和多发性骨髓瘤临床疗效的一种有前途的途径。产生活性氧的治疗方式(即辐射、光动力治疗和特定的化疗药物)已被证明对恶性B细胞具有选择性的细胞毒作用。在这篇综述中，我们将讨论通过氧化应激诱导B细胞肿瘤细胞凋亡的因素。随后，将讨论将氧化应激源与放疗和化疗相结合的新的生化原理(基于癌症和正常细胞氧化代谢的根本差异)，这可能导致设计更有效的B细胞恶性肿瘤治疗策略。除了提供潜在的疗效外，这些新的治疗方法还可以选择性地靶向和抑制肿瘤细胞中耐药的出现，这是许多B细胞恶性肿瘤治疗失败的主要决定因素。
Developing novel combined-modality therapeutic approaches based on understanding of the involvement of redox biology in apoptosis of malignant cells is a promising approach for improving clinical responses in B-cell lymphoma and multiple myeloma. Therapeutic modalities that generate reactive oxygen species (i.e., radiation, photodynamic therapy, and specific chemotherapeutic drugs) have been shown to be selectively cytotoxic to malignant B-cells. In this review, we will discuss agents that induce apoptosis in B-cell tumors by oxidative stress. Subsequently, a novel biochemical rationale (based on fundamental differences in cancer vs. normal cell oxidative metabolism) for combining oxidative stressors with radiotherapy and chemotherapy, that may lead to designing of more effective treatment strategies for B-cell malignancies, will be discussed. Besides providing potential curative benefit, such novel therapies could also selectively target and inhibit the emergence of drug-resistance in tumor cells, which is a major determinant of treatment failure in many B-cell malignancies.
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DOI：
10.1158/1078-0432.ccr-07-4568
发表时间：
2008-08-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Burington B;Barlogie B;Zhan F;Crowley J;Shaughnessy JD Jr
通讯作者：
Shaughnessy JD Jr
影响因子：
20.3
作者：
Bellosillo, B;Villamor, N;Montserrat, E
通讯作者：
Montserrat, E
影响因子：
4.8
作者：
Golab, J;Nowis, D;Jakóbisiak, M
通讯作者：
Jakóbisiak, M
影响因子：
2.8
作者：
Battisti, Vanessa;Maders, Liesi D. K.;Morsch, Vera M.
通讯作者：
Morsch, Vera M.
影响因子：
4.8
作者：
DOUGALL, WC;NICK, HS
通讯作者：
NICK, HS