Identification of plasma inactive renin as prorenin with a site-directed antibody.

Identification of plasma inactive renin as prorenin with a site-directed antibody.
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使用定点抗体将血浆无活性肾素鉴定为肾素原。

DOI:
10.1016/0006-291x(85)90232-3
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发表时间:
1985
影响因子:
3.1
通讯作者:
Kazuo Murakami
Kazuo Murakami
中科院分区:
生物学4区
文献类型:
--
作者:
Seong;Shigehisa Hirose;Hitoshi Miyazaki;Naoto Ueno;Koichi Higashimori;Shojiro Morinaga;Terutoshi Kimura;Shumpei Sakakibara;Kazuo Murakami

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一个序列特异性抗体,识别人肾素前体的前片段的一部分,并提出和用于提供直接证据,血浆中的非活性的肾素含有肾肾素的前序列,因此可能是原肾素,而不是一个失活的形式,以前活跃的肾素。这些信息不仅有助于解决关于人血浆中无活性肾素性质的重大争议,而且有助于阐明其确切的生理作用。
A sequence-specific antibody that recognizes a portion of the prosegment of human renin precursor was raised and used to provide direct evidence that plasma inactive renin contains the prosequence of renal renin and is therefore probably prorenin rather than an inactivated form of previously active renin. The information may help not only to resolve a major controversy concerning the nature of inactive renin in human plasma but also to elucidate its exact physiological role.
肾素原和其他大分子量形式的肾素。
DOI: 10.1210/edrv-1-4-365
发表时间: 1980
期刊: Endocrine reviews
影响因子: 20.3
作者:
Sealey,JE;Atlas,SA;Laragh,JH
通讯作者: Laragh,JH
人类肾脏和血浆中的一种无活性的肾素原样物质。
DOI: 10.1042/cs059029s
发表时间: 1980
期刊: Clinical science (London, England : 1979)
影响因子: --
作者:
Atlas,SA;Laragh,JH;Sealey,JE;Hesson,TE
通讯作者: Hesson,TE