Influence of acid-pepsin secretion on gastric emptying of solids in humans: studies with cimetidine.
Influence of acid-pepsin secretion on gastric emptying of solids in humans: studies with cimetidine.
复制标题
胃酸分泌对人体胃固体排空的影响：西咪替丁的研究。
作者：
D. Kerrigan;Y. Mangnall;N. Read;A. Johnson
普遍接受的胃排空模型表明，“胃窦磨”负责磨碎和随后从胃排空固体食物。对其他消化机制如酸性胃蛋白酶分泌对固体排空的贡献知之甚少。我们研究了抑制胃分泌对固体试验餐从胃排空速率的影响。我们使用放射性标记的牛肉汉堡，对10名禁食的健康志愿者连续几天进行配对伽玛摄像机研究，以比较有和没有口服西咪替丁（测试前1小时400 mg，开始时800 mg）的测试餐的胃排空。膳食）。西咪替丁对酸性胃蛋白酶分泌的抑制作用与汉堡从胃中排空速率的明显延迟有关（T50西咪替丁187（16）min（平均值（SEM）; T50无西咪替丁146（15）min; p <0.01，配对t检验）。这种延迟与排空曲线斜率的变化有关，与延迟期延长无关。这些结果可能是由于西咪替丁引起的相对无氯和胃蛋白酶活性降低，损害了固体食物分解成足够小的颗粒离开胃。
The commonly accepted model for gastric emptying suggests that the 'antral mill' is responsible for the triturition and subsequent emptying of solid food from the stomach. Little is known about the contribution to solid emptying made by other digestive mechanisms such as acid-pepsin secretion. We have investigated the effect of inhibiting gastic secretion on the rate at which a solid test meal emptied from the stomach. Using a radiolabelled beefburger, we performed paired gammacamera studies on consecutive days in 10 fasted, healthy volunteers to compare gastric emptying of the test meal with and without oral cimetidine (400 mg 1 hour before the test, 800 mg at the start of the meal). Inhibition of acid-pepsin secretion by cimetidine was associated with an appreciable delay in the rate of emptying of the burger from the stomach (T50 cimetidine 187 (16) min (mean (SEM); T50 no cimetidine 146 (15) min; p less than 0.01, paired t test). This delay was related to a change in the slope of the emptying profile and was not associated with a prolonged lag phase. These results may be explained by the relative achlorhydria and reduced pepsin activity induced by cimetidine impairing the breakdown of solid food into particles small enough to leave the stomach.
影响因子：
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作者：
AZPIROZ, F;MALAGELADA, JR
通讯作者：
MALAGELADA, JR