Differential insulin sensitivities of glucose, amino acid, and albumin metabolism in elderly men and women.
Differential insulin sensitivities of glucose, amino acid, and albumin metabolism in elderly men and women.
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老年男性和女性葡萄糖、氨基酸和白蛋白代谢的胰岛素敏感性差异。
DOI：
10.1210/jcem.86.2.7193
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
B. Beaufrère
中科院分区：
文献类型：
--
作者：
Y. Boirie;P. Gachon;N. Cordat;P. Ritz;B. Beaufrère
胰岛素对葡萄糖稳态的调节在衰老过程中会发生变化，但这种变化是否与蛋白质代谢的变化有关尚不清楚。用D-[6，6-（2）H（2）]葡萄糖和L-[1-（13）C]亮氨酸同位素稀释法研究了14名青年人全身葡萄糖、亮氨酸和白蛋白代谢的胰岛素剂量反应（Y; 24.0 ± 0.9岁;平均值± SEM，20.5 ± 0.4 kg/m2）和12名健康老年受试者（英; 69.4 ± 0.6岁; 24.6 +/- 0.8 kg/m2），采用正葡萄糖和正氨基酸高胰岛素钳夹，以0.2和0.5 mU/kg.min的两种胰岛素输注速率（分别为CL 1和CL 2）。尽管E组的血浆胰岛素显著高于Y组，但在两种胰岛素水平下，E组的葡萄糖处置率均低于Y组，而葡萄糖的产生通常受到抑制。在CL 1时，E中胰岛素对全身蛋白质分解的抑制作用小于Y中胰岛素对全身蛋白质分解的抑制作用（-13.5 +/- 1.4% vs. -8.8 +/-1.3%，Y vs. E，P < 0.05），但在CL 2时不显著（-22.0 +/- 1.4% vs. -18.8 +/-1.7%，Y vs. E，P = NS）。Y组和E组的白蛋白合成速率相同，胰岛素对白蛋白合成的刺激程度相同。性别影响基础亮氨酸代谢，但两组对胰岛素的反应相似。总之，在低胰岛素浓度的健康老年受试者中，胰岛素对葡萄糖处置的作用降低与胰岛素对蛋白质分解的敏感性降低相关。较高的胰岛素水平补偿了老年受试者中胰岛素对蛋白质代谢作用的降低。
Regulation of glucose homeostasis by insulin is modified during aging, but whether this alteration is associated with changes in protein metabolism is less defined. Insulin dose responses of whole body glucose, leucine, and albumin metabolism have been investigated using isotopic dilution of D-[6, 6-(2)H(2)]glucose and L-[1-(13)C]leucine in 14 young (Y; 24.0 +/- 0.9 yr; mean +/- SEM, 20.5 +/- 0.4 kg/m(2)) and 12 healthy elderly subjects (E; 69.4 +/- 0.6 yr; 24.6 +/- 0.8 kg/m(2)) using a euglycemic and euaminoacidemic hyperinsulinemic clamp at two insulin infusion rates of 0.2 and 0.5 mU/kg.min (CL1 and CL2, respectively). Despite significantly higher plasma insulin in E than in Y, the glucose disposal rate was lower in E than in Y at both insulin levels, whereas glucose production was normally suppressed. Whole body protein breakdown was less inhibited by insulin in E than in Y at CL1 (-13.5 +/- 1.4% vs. -8.8 +/- 1.3%, Y vs. E, P < 0.05), but not significantly at CL2 (-22.0 +/- 1.4% vs. -18.8 +/- 1.7%, Y vs. E, P = NS). The albumin synthesis rate was identical and stimulated to the same extent by insulin in groups Y and E. Gender affected basal leucine metabolism, but the response to insulin was similar in both groups. In conclusion, decreased insulin action on glucose disposal is associated with a reduced insulin sensitivity for protein breakdown in healthy elderly subjects at low insulin concentrations. Higher insulin levels compensate for a reduced insulin action on protein metabolism in elderly subjects.
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影响因子：
15.9
作者：
ROWE, JW;MINAKER, KL;FLIER, JS
通讯作者：
FLIER, JS
影响因子：
15.9
作者：
Price, SR;Bailey, JL;Mitch, WE
通讯作者：
Mitch, WE
DOI：
10.1152/ajpendo.1996.270.2.e273
发表时间：
1996-02-01
影响因子：
5.1
作者：
Luzi, L;Castellino, P;DeFronzo, RA
通讯作者：
DeFronzo, RA
DOI：
10.1152/ajpendo.1989.256.2.e288
发表时间：
1989-02
期刊：
The American journal of physiology
影响因子：
--
作者：
N. Fukagawa;K. Minaker;V. Young;D. Matthews;D. Bier;J. Rowe
通讯作者：
N. Fukagawa;K. Minaker;V. Young;D. Matthews;D. Bier;J. Rowe
儿童极度脂肪营养不良中胰岛素代谢作用的不一致。
DOI：
10.1210/jcem.77.5.8077317
发表时间：
1993
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Copeland,KC;Nair,KS;Kaplowitz,PB;Robbins,DC;Calles-Escandon,J
通讯作者：
Calles-Escandon,J