Target-related patterns of co-existence of neuropeptide Y, vasoactive intestinal peptide, enkephalin and substance P in cranial parasympathetic neurons innervating the facial skin and exocrine glands of guinea-pigs
Target-related patterns of co-existence of neuropeptide Y, vasoactive intestinal peptide, enkephalin and substance P in cranial parasympathetic neurons innervating the facial skin and exocrine glands of guinea-pigs
复制标题
神经肽 Y、血管活性肠肽、脑啡肽和 P 物质在支配豚鼠面部皮肤和外分泌腺的颅副交感神经元中共存的目标相关模式
DOI：
10.1016/0306-4522(90)90049-a
复制
发表时间：
1990
期刊：
影响因子：
3.3
通讯作者：
I. Gibbins
中科院分区：
文献类型：
--
作者：
I. Gibbins
采用定量双标记免疫荧光法和Fast Blue逆行轴突示踪法研究了豚鼠颅自主神经元中神经肽的共存模式。在蝶腭神经节、耳神经节、舌下神经节和下颌下神经节以及与舌咽神经相关的一个突出的颅内神经节内，大多数神经元含有血管活性肠肽、神经肽Y、脑啡肽和P物质的免疫反应性，其组合与其投射相关。面部皮肤的毛囊形成蝶腭神经节细胞的主要靶点。这些神经元中共存的肽的组合取决于毛囊所在的皮肤区域。腮腺受耳神经节或颅内神经节内具有胞体的神经元支配。大多数神经元对这四种多肽都具有免疫反应性。舌下腺受局部神经节细胞支配，通常对神经肽Y、血管活性肠肽和p物质具有免疫反应性。颌下腺受局部神经节细胞支配，其中含有脑啡肽免疫反应性和对神经肽Y的低水平免疫反应性。包括不到10%的颅自主神经节细胞。这些结果表明，神经肽在颅自主神经元中的共存模式具有高度的靶特异性。毛囊形成一个主要的副交感神经靶点的发现意味着颅自主神经元的活动范围比迄今为止所怀疑的要广泛。
The patterns of co-existence of neuropeptides in cranial autonomic neurons of guinea-pigs have been examined with quantitative double-labelling immunofluorescence and retrograde axonal tracing using Fast Blue. Within the sphenopalatine, otic, sublingual and submandibular ganglia, and a prominent intracranial ganglion associated with the glossopharyngeal nerve, most neurons contained immuno-reactivity of vasoactive intestinal peptide, neuropeptide Y, enkephalin and substance P in combinations that were correlated with their projections. Hair follicles in the facial skin formed a major target of sphenopalatine ganglion cells. The combinations of peptides co-existing in these neurons depended upon the region of the skin where the follicles were located. The parotid gland was innervated by neurons with cell bodies in the otic ganglion or the intracranial ganglion. Most of these neurons contained immunoreactivity to all four peptides. The sublingual gland was innervated by local ganglion cells usually containing immunoreactivity to neuropeptide Y, vasoactive intestinal peptide and substance P. The submandibular gland was innervated by local ganglion cells containing enkephalin immunoreactivity and low levels of immunoreactivity to neuropeptide Y. Presumptive vasodilator neurons, containing immuno-reactivity to vasoactive intestinal peptide but no other peptide examined here, comprised less than 10% of cranial autonomie ganglion cells.These results demonstrate that the patterns of co-existence of neuropeptides in cranial autonomic neurons show a high degree of target specificity. The discovery that hair follicles form a major parasympathetic target implies a broader range of actions of cranial autonomie neurons than has been suspected until now.
从猫的蝶腭和耳神经节到大脑中动脉的脑血管投射。
影响因子：
8.3
作者：
Walters,BB;Gillespie,SA;Moskowitz,MA
通讯作者：
Moskowitz,MA
大鼠颅副交感神经元中的神经肽 Y 样免疫反应性：与血管活性肠肽和胆碱乙酰转移酶共存。
DOI：
10.1073/pnas.84.10.3511
发表时间：
1987
影响因子：
11.1
作者：
Leblanc,GG;Trimmer,BA;Landis,SC
通讯作者：
Landis,SC