Operon prediction by Markov clustering

Operon prediction by Markov clustering
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通过马尔可夫聚类预测操纵子

DOI:
10.1504/ijdmb.2014.062149
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发表时间:
2014-05
影响因子:
0.3
通讯作者:
杜伟
杜伟
中科院分区:
生物学4区
文献类型:
--
作者:
杜伟

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The prediction of operons is a critical step for the reconstruction of biochemical and regulatory networks at the whole genome level. In this paper, a novel operon prediction model is proposed based on Markov Clustering (MCL). The model employs a graph-clustering method by MCL for prediction and does not need a classifier. In the cross-species validation, the accuracies of E. coli K12, Bacillus subtilis and P. furiosus are 92.1, 86.9 and 87.3%, respectively. Experimental results show that the proposed method has a powerful capability of operon prediction. The compiled program and test data sets are publicly available at http://ccst.jlu.edu.cn/JCSB/OPMC/.
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