Kynurenine is an endothelium-derived relaxing factor produced during inflammation.
Kynurenine is an endothelium-derived relaxing factor produced during inflammation.
复制标题
DOI：
10.1038/nm.2092
复制
发表时间：
2010-03
期刊：
影响因子：
82.9
通讯作者：
Stocker, Roland
中科院分区：
文献类型：
--
作者：
Wang, Yutang;Liu, Hanzhong;McKenzie, Gavin;Witting, Paul K.;Stasch, Johannes-Peter;Hahn, Michael;Changsirivathanathamrong, Dechaboon;Wu, Ben J.;Ball, Helen J.;Thomas, Shane R.;Kapoor, Vimal;Celermajer, David S.;Mellor, Andrew L.;Keaney, John F., Jr.;Hunt, Nicholas H.;Stocker, Roland
Control of blood vessel tone is central to vascular homeostasis. Here, we show that metabolism of tryptophan to kynurenine by indoleamine 2,3-dioxygenase (IDO) expressed in endothelial cells contributes to arterial vessel relaxation and the control of blood pressure. Infection of mice with malarial parasites (Plasmodium berghei), and experimental induction of endotoxemia, caused endothelial expression of IDO, resulting in decreased plasma tryptophan, increased kynurenine, and hypotension. Pharmacological inhibition of IDO increased blood pressure in systemically inflamed mice, but not in mice deficient for IDO or interferon-γ, which is required for IDO induction. Tryptophan dilated pre-constricted porcine coronary arteries only if active IDO and an intact endothelium were both present. Kynurenine dose-dependently decreased blood pressure in spontaneously hypertensive rats, inhibited contraction of arteries, and relaxed pre-constricted rings endothelium-independently. Arterial relaxation by kynurenine was mediated by activation of the adenylate and soluble guanylate cyclase pathways.
登录
查看更多内容
DOI：
10.1016/s1385-299x(02)00147-2
发表时间：
2002-06-01
期刊：
BRAIN RESEARCH PROTOCOLS
影响因子：
--
作者：
Ball, HJ;McParland, B;Hunt, NH
通讯作者：
Hunt, NH
影响因子：
82.9
作者：
Gramaglia, Irene;Sobolewski, Peter;van der Heyde, Henri C.
通讯作者：
van der Heyde, Henri C.
影响因子：
4.8
作者：
Connelly, L;Madhani, M;Hobbs, AJ
通讯作者：
Hobbs, AJ
影响因子：
4.4
作者：
Jung, In Duk;Lee, Min-Goo;Park, Yeong-Min
通讯作者：
Park, Yeong-Min
影响因子：
8.8
作者：
GOMEZJIMENEZ, J;SALGADO, A;MONCADA, S
通讯作者：
MONCADA, S