Transmission Of Tuberculosis Among illicit drug use Linkages (TOTAL): A cross-sectional observational study protocol using respondent driven sampling.
Transmission Of Tuberculosis Among illicit drug use Linkages (TOTAL): A cross-sectional observational study protocol using respondent driven sampling.
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非法药物使用联系之间结核病的传播（总计）：使用受访者驱动的抽样的横断面观察研究方案。
DOI：
10.1371/journal.pone.0262440
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发表时间：
2022
期刊：
影响因子：
3.7
通讯作者：
Jacobson KR
中科院分区：
文献类型：
--
作者：
Carney T;Rooney JA;Niemand N;Myers B;Theron D;Wood R;White LF;Meade CS;Chegou NN;Ragan E;Walzl G;Horsburgh R;Warren RM;Jacobson KR
使用非法药物（PWUDs）的人已被确定为结核病（TB）的关键风险群体。对非法药物使用网络的检查有可能评估结核病暴露和疾病进展的风险。还需要进行研究，以评估结核病在这一人群中加速传播的机制。本研究旨在：1）评估PWUD的结核病暴露率、疾病进展风险和疾病负担; 2）估计该网络内近期传播导致的活动性结核病例比例; 3）评估患有结核病的PWUD是否具有与更有效的结核病传播相关的生理特征。我们的横断面观察性研究旨在评估结核病通过非法药物使用网络的传播，重点是在结核病高负担环境中使用甲基苯丙胺和Mandrax（甲喹酮），并确定加速传播的机制。我们将通过在南非伍斯特的受试者驱动抽样招募和入组750名PWUD（感染和未感染艾滋病毒）。将通过自我报告和生物学措施测量药物使用情况，采集痰液标本，通过Xpert Ultra（Cepheid）和分枝杆菌培养识别结核病。我们将在目标2中共同招募那些有结核病微生物学证据的人进行分子和社会网络研究。将对诊断为结核病的人进行结核分枝杆菌（Mtb）标本的全基因组测序和社会接触调查。对于目标3，将在吸食和不吸食非法药物的新诊断结核病患者中比较雾化的结核病。这项研究的知识将为在PWUD中断结核病传播的战略提供基础，并深入了解结核病传播如何促进整个社区的传播。研究结果有可能为减少结核病传播的干预措施提供信息，适用于结核病和艾滋病毒高负担环境。试用注册：Clinicaltrials.gov注册号：NCT 041515602。注册日期：2019年11月5日。
People who use illicit drugs (PWUDs) have been identified as a key at-risk group for tuberculosis (TB). Examination of illicit drug use networks has potential to assess the risk of TB exposure and disease progression. Research also is needed to assess mechanisms for accelerated TB transmission in this population. This study aims to 1) assess the rate of TB exposure, risk of disease progression, and disease burden among PWUD; 2) estimate the proportion of active TB cases resulting from recent transmission within this network; and 3) evaluate whether PWUD with TB disease have physiologic characteristics associated with more efficient TB transmission. Our cross-sectional, observational study aims to assess TB transmission through illicit drug use networks, focusing on methamphetamine and Mandrax (methaqualone) use, in a high TB burden setting and identify mechanisms underlying accelerated transmission. We will recruit and enroll 750 PWUD (living with and without HIV) through respondent driven sampling in Worcester, South Africa. Drug use will be measured through self-report and biological measures, with sputum specimens collected to identify TB disease by Xpert Ultra (Cepheid) and mycobacterial culture. We will co-enroll those with microbiologic evidence of TB disease in Aim 2 for molecular and social network study. Whole genome sequencing of Mycobacteria tuberculosis (Mtb) specimens and social contact surveys will be done for those diagnosed with TB. For Aim 3, aerosolized Mtb will be compared in individuals with newly diagnosed TB who do and do not smoke illicit drug. Knowledge from this study will provide the basis for a strategy to interrupt TB transmission in PWUD and provide insight into how this fuels overall community transmission. Results have potential for informing interventions to reduce TB spread applicable to high TB and HIV burden settings. Trial registration: Clinicaltrials.gov Registration Number: NCT041515602. Date of Registration: 5 November 2019.
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影响因子：
5.5
作者：
Gotway, MB;Marder, SR;Webb, WR
通讯作者：
Webb, WR
影响因子：
7.7
作者：
Leavitt, Sarah, V;Lee, Robyn S.;White, Laura F.
通讯作者：
White, Laura F.
DOI：
10.1016/j.tube.2017.11.009
发表时间：
2018-03
期刊：
Tuberculosis (Edinburgh, Scotland)
影响因子：
--
作者：
Fiore-Gartland A;Carpp LN;Naidoo K;Thompson E;Zak DE;Self S;Churchyard G;Walzl G;Penn-Nicholson A;Scriba TJ;Hatherill M
通讯作者：
Hatherill M
DOI：
10.1111/rssa.12059
发表时间：
2015-01
期刊：
Journal of the Royal Statistical Society. Series A, (Statistics in Society)
影响因子：
--
作者：
Gile KJ;Johnston LG;Salganik MJ
通讯作者：
Salganik MJ
影响因子：
10.7
作者：
Nguyen LT;Schmidt HA;von Haeseler A;Minh BQ
通讯作者：
Minh BQ