A novel ejection protein from bacteriophage 80α that promotes lytic growth.
A novel ejection protein from bacteriophage 80α that promotes lytic growth.
复制标题
来自噬菌体80α的新型射血蛋白可促进裂解生长。
DOI：
10.1016/j.virol.2018.09.025
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发表时间：
2018-12
期刊：
影响因子：
3.7
通讯作者：
Dokland T
中科院分区：
文献类型：
--
作者：
Manning KA;Quiles-Puchalt N;Penadés JR;Dokland T
Many staphylococcal bacteriophages encode a minor capsid protein between the genes for the portal and scaffolding proteins. In Staphylococcus aureus bacteriophage 80α, this protein, called gp44, is essential for the production of viable phage, but dispensable for the phage-mediated mobilization of S. aureus pathogenicity islands. We show here that gp44 is not required for capsid assembly, DNA packaging or ejection of the DNA, nor for generalized transduction of plasmids. An 80α Δ44 mutant could be complemented in trans by gp44 expressed from a plasmid, indicating that gp44 plays a role in the host post-injection. Our results show that gp44 is an ejection (pilot) protein that is involved in deciding the fate of the phage DNA after injection. Our data are consistent with a model in which gp44 acts as a regulatory protein that promotes progression to the lytic cycle.
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DOI：
10.1126/science.1231887
发表时间：
2013-02-01
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Hu B;Margolin W;Molineux IJ;Liu J
通讯作者：
Liu J
影响因子：
5.6
作者：
Hill, Rosanne L. L.;Dokland, Terje
通讯作者：
Dokland, Terje
影响因子：
5.6
作者：
Dröge, A;Santos, MA;Tavares, P
通讯作者：
Tavares, P
影响因子：
5.6
作者：
Dearborn, Altaira D.;Spilman, Michael S.;Dokland, Terje
通讯作者：
Dokland, Terje
影响因子：
3.8
作者：
Das, Malabika;Ganguly, Tridib;Sau, Subrata
通讯作者：
Sau, Subrata