Amitriptyline, clovoxamine and cognitive function: a placebo-controlled comparison in depressed outpatients
Amitriptyline, clovoxamine and cognitive function: a placebo-controlled comparison in depressed outpatients
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阿米替林、氯氧沙明和认知功能：抑郁症门诊患者的安慰剂对照比较
作者：
B. Spring;A. Gelenberg;R. Garvin;Sheri Thompson
三环类抗抑郁药不再仅用于治疗抑郁症的植物体征，它还可以减轻抑郁症认知扭曲。不太清楚的是它们是否可以改善抑郁症患者在记忆、信息处理速度和精神运动表现方面的其他认知缺陷。我们测试了另一种假设，即阿米替林由于其抗胆碱能和镇静特性，会加剧抑郁症患者的认知障碍。抑郁症门诊患者接受双盲安慰剂 (n=15)、阿米替林 (n=10) 或富马酸氯伏沙明 (n=10)（一种相对缺乏抗胆碱能特性的血清素再摄取抑制剂）。在基线以及药物治疗 7 天和 28 天后评估抑郁、记忆和精神运动表现。经过所有治疗（包括安慰剂）后，抑郁症得到缓解。只有阿米替林会损害记忆测试的表现，在治疗 4 周后，相对于安慰剂，记忆力显着下降。所有治疗均不会对精神运动任务的表现产生不利影响。这些发现进一步证明，具有高抗胆碱能活性的抗抑郁药物尽管可以缓解抑郁症，但仍会损害记忆力。
No longer prescribed only for vegetative signs of depression, tricyclic antidepressants also lessen depressive cognitive distortions. Less clear is whether they ameliorate depressed patients' other cognitive deficits in memory, information processing speed, and psychomotor performance. We tested the alternative hypothesis that amitriptyline, because of its anticholinergic and sedative properties, would exacerbate depressed patients' cognitive disturbances. Depressed outpatients received double-blind placebo (n=15), amitriptyline (n=10), or clovoxamine fumarate (n=10), a serotonin reuptake inhibitor relatively lacking in anticholinergic properties. Depression, memory, and psychomotor performance were assessed at baseline and after 7 and 28 days of drug treatment. Depression was alleviated after all treatments, including placebo. Only amitriptyline impaired performance on tests of memory, producing a significant decrement, relative to placebo, after 4 weeks of treatment. None of the treatments adversely affected performance on psychomotor tasks. These findings add to the evidence that antidepressant drugs with high anticholinergic activity can impair memory, despite alleviation of depression.
抑郁症认知治疗和药物治疗的变化过程。
影响因子：
--
作者：
Simons,AD;Garfield,SL;Murphy,GE
通讯作者：
Murphy,GE
抑郁症比较结果研究中的患者流失。
影响因子：
6.6
作者：
Simons,AD;Levine,JL;Lustman,PJ;Murphy,GE
通讯作者：
Murphy,GE