The long-term cognitive consequences of adolescent exposure to recreational drugs of abuse.
The long-term cognitive consequences of adolescent exposure to recreational drugs of abuse.
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DOI：
10.1101/lm.046672.117
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发表时间：
2018-09
期刊：
影响因子：
--
通讯作者：
Gould TJ
中科院分区：
文献类型：
--
作者：
Mooney-Leber SM;Gould TJ
在青春期，大脑继续经历重要的发育过程。反过来，复杂的行为和认知技能应运而生。不幸的是，青春期的神经生物学发展可能会受到环境因素的影响，如药物暴露。青春期吸毒一直是一个长期的健康问题，特别是它如何预测或与以后的吸毒行为有关。然而，最近的发现表明，其他行为领域，如学习和记忆，也容易受到青少年药物使用的影响。此外，越来越明显的是，青少年吸毒后的学习和记忆缺陷一直持续到成年，很久以前毒品暴露已经消退。尽管持续的影响表明药物暴露与青春期持续发育之间存在相互作用，但青少年药物暴露对学习和记忆底物的确切急性和长期后果尚不完全清楚。因此，这篇综述将总结人类和动物对青少年药物暴露造成的持久认知缺陷的研究结果。此外，由于青少年更有可能消费成年人合法获得的滥用药物，这次审查将集中在酒精、尼古丁和大麻上。此外，鉴于额叶皮质和海马体在不同的学习和记忆领域中的关键作用，也将讨论青少年使用先前列出的药物对这些区域内神经生物学的影响。
During adolescence, the brain continues to undergo vital developmental processes. In turn, complex behavioral and cognitive skills emerge. Unfortunately, neurobiological development during adolescence can be influenced by environmental factors such as drug exposure. Engaging in drug use during adolescence has been a long-standing health concern, especially how it predicts or relates to drug using behavior later in life. However, recent findings suggest that other behavioral domains, such as learning and memory, are also vulnerable to adolescent drug use. Moreover, it is becoming increasingly apparent that deficits in learning and memory following adolescent drug use endure into adulthood, well after drug exposure has subsided. Although persistent effects suggest an interaction between drug exposure and ongoing development during adolescence, the exact acute and long-term consequences of adolescent drug exposure on substrates of learning and memory are not fully understood. Thus, this review will summarize human and animal findings on the enduring cognitive deficits due to adolescent drug exposure. Moreover, due to the fact that adolescents are more likely to consume drugs of abuse legally available to adults, this review will focus on alcohol, nicotine, and marijuana. Further, given the critical role of the frontal cortex and hippocampus in various learning and memory domains, the impact adolescent use of the previous listed drugs on the neurobiology within these regions will also be discussed.
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乙醇暴露对提示和上下文恐惧条件和灭绝的后果因青春期或成年期暴露时间而有所不同。
影响因子：
2.7
作者：
Broadwater, Margaret;Spear, Linda P.
通讯作者：
Spear, Linda P.
青少年暴饮暴食改变了小鼠的成人脑神经递质的表达，行为，大脑区域体积和神经化学。
DOI：
10.1111/j.1530-0277.2010.01385.x
发表时间：
2011-04
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
Coleman LG Jr;He J;Lee J;Styner M;Crews FT
通讯作者：
Crews FT
影响因子：
2.9
作者：
Broadwater MA;Liu W;Crews FT;Spear LP
通讯作者：
Spear LP
影响因子：
3.5
作者：
Barha, Cindy K.;Brummelte, Susanne;Galea, Liisa A. M.
通讯作者：
Galea, Liisa A. M.
影响因子：
4.4
作者：
Charles, Nora E.;Mathias, Charles W.;Dougherty, Donald M.
通讯作者：
Dougherty, Donald M.