Effective chemotherapy of acute myelocytic leukemia occurring after alkylating agent or radiation therapy for prior malignancy.
Effective chemotherapy of acute myelocytic leukemia occurring after alkylating agent or radiation therapy for prior malignancy.
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对既往恶性肿瘤进行烷化剂或放射治疗后发生的急性粒细胞白血病的有效化疗。
DOI：
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发表时间：
1983
影响因子：
45.3
通讯作者：
P. Burke
中科院分区：
文献类型：
--
作者：
W. Vaughan;J. Karp;P. Burke
Eleven consecutive patients with acute myelocytic leukemia occurring as a second malignancy were treated with high-dose, timed, sequential chemotherapy. Eight of the patients were felt to have "secondary" acute leukemia because they had received an alkylating agent or radiation therapy. The other three patients were considered controls. Despite a median age of 65, four of the eight secondary leukemia patients achieved complete remission with this regimen. One of the three control patients also achieved complete remission. This remission rate and duration are comparable to what was achieved with this treatment of "primary" acute myelocytic leukemia during the same period of time. These results suggest that patients with leukemia occurring after an alkylating agent or radiation therapy are not at especially high risk if treated aggressively.
影响因子：
3.1
作者：
J. Rowley;H. Golomb;J. Vardiman
通讯作者：
J. Rowley;H. Golomb;J. Vardiman