Treatment patterns and medication adherence of patients with glaucoma in South Korea.
Treatment patterns and medication adherence of patients with glaucoma in South Korea.
复制标题
DOI：
10.1136/bjophthalmol-2016-308505
复制
发表时间：
2017-06
期刊：
影响因子：
--
通讯作者：
Kim YJ
中科院分区：
文献类型：
--
作者：
Kim CY;Park KH;Ahn J;Ahn MD;Cha SC;Kim HS;Kim JM;Kim MJ;Kim TW;Kim YY;Lee JW;Park SW;Sohn YH;Sung KR;Yoo C;Cha J;Kim YJ
本研究旨在调查青光眼的治疗模式和药物依从性。它还确定了与不遵守相关的关键因素。这是一项横断面观察性研究。 2013年3月至11月期间，在15家眼科诊所招募了使用眼药水≤2 年的患者。通过自填问卷和病历审查收集数据。用药依从性通过患者自我报告的药片计数进行评估，并定义为患者用药时间≥处方天数的 80%。用药依从率通过实际给药次数除以7 天内规定的总给药次数来计算。自我报告的处方与医生处方的每日总剂量不同的患者被视为不依从。总共纳入了 1050 名患者，并对 1046 名可获得依从性验证的患者进行了药物依从率评估。其中，不依从者占27.4%，总体、依从者和不依从者的用药依从率分别为90.6±17.8%、96.8±5.5%和56.6±24.7%。最常用的药物是单独的前列腺素（PGA），其次是两类药物（β-阻滞剂和碳酸酐酶抑制剂（CAI））的组合，其次是PGA、β-阻滞剂和CAI的三类组合。在多变量分析中，男性不依从的风险是女性的 1.466 倍（95% CI 1.106 至 1.943），并且随着每日给药次数的增加，不依从风险增加 1.328 倍（95% CI 1.186 至 1.487）。大约三分之一的患者不依从，男性和每日给药次数增加与不依从相关。它强调应考虑更系统的治疗策略，以提高用药依从性，从而实现有效的青光眼管理。
This study aimed to investigate treatment patterns and medication adherence of glaucoma. It also identified key factors associated with non-adherence. It was a cross-sectional, observational study. Patients who use eye-drops for ≤2 years were recruited at 15 eye clinics from March to November 2013. Data were collected through self-administered questionnaires and medical chart review. Medication adherence was evaluated using patients’ self-report on pill count and defined as patients’ administering drug for ≥80% of prescribed days. Medication adherence rate was calculated by dividing actual number of administration from total prescribed number of administration for 7 days. Patients whose self-reported prescription was different from total daily doses of physicians' prescription were considered as non-adherent. A total of 1050 patients included, and medication adherence rate was evaluated in 1046 patients whose verification of adherence was available. Of the total, 27.4% were non-adherent, and the medication adherence rates of the total, the adherent, and the non-adherent were 90.6±17.8%, 96.8±5.5% and 56.6±24.7%, respectively. The most commonly used medication was prostaglandin (PGA) alone and the second was combination of two-class (β-blocker and carbonic anhydrase inhibitor (CAI)) and three-class combination of PGA, β-blocker and CAI followed. In multivariate analysis, the risk of non-adherence was 1.466 times greater in males than in females (95% CI 1.106 to 1.943) and 1.328-fold greater as the daily number of administration was increased (95% CI 1.186 to 1.487). Approximately, one-third of the patients were non-adherent, and males and increased daily number of administration were associated with non-adherence. It highlights that more systematic treatment strategies should be considered for better medication adherence, leading to effective glaucoma management.
登录
查看更多内容
影响因子：
13.7
作者：
Kosoko, O;Quigley, HA;Tielsch, JM
通讯作者：
Tielsch, JM
影响因子：
0.8
作者：
Busche, S;Gramer, E
通讯作者：
Gramer, E
影响因子：
2.9
作者：
Martin, Bradley C.;Wiley-Exley, Elizabeth K.;Sleath, Betsy Lynn
通讯作者：
Sleath, Betsy Lynn
影响因子：
13.7
作者：
Sleath, B;Robin, AL;Svarstad, B
通讯作者：
Svarstad, B
影响因子：
2.3
作者：
Taylor, SA;Galbraith, SM;Mills, RP
通讯作者：
Mills, RP