Effect of ring size on conformation and biological activity of cyclic cationic antimicrobial peptides.
Effect of ring size on conformation and biological activity of cyclic cationic antimicrobial peptides.
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DOI：
10.1021/jm801648n
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发表时间：
2009-04-09
影响因子：
7.3
通讯作者：
Hodges RS
中科院分区：
文献类型：
--
作者：
Jelokhani-Niaraki M;Kondejewski LH;Wheaton LC;Hodges RS
在一系列基于 GS10（短杆菌肽 S (GS) 类似物）的环肽中，环大小从 10 到 16 个氨基酸不等。在原始 GS10 构建体中交替添加碱性和疏水性氨基酸，生成各种偶数环，即 GS10 [环-(VKLdYPVKLdYP)]、GS12 [环-(VKLKdYPKVKLdYP)]、GS14 [环-(VKLKVdYPLKVKLdYP) 和 GS16 [环-(VKLKVKdYPKLKVKLdYP)]（d代表D-对映体）。奇数类似物（11、13 和 15 聚体）是通过添加或删除单个碱性 (Lys) 或疏水性（Leu 或 Val）氨基酸而衍生自这四种肽。所得肽根据肽环大小分为三组（10 至 12 聚体、13 和 14 聚体、以及 15 和 16 聚体），展示了与其环大小、β 结构破坏程度、电荷、疏水性、两亲性和脂膜亲和力相关的多种生物活性。其中两种肽具有有效的抗菌活性和高治疗指数（与 GS 相比为 4.5-10 倍），是开发广谱抗生素的有希望的候选肽。
In a series of cyclic peptides based on GS10, an analog of gramicidin S (GS), the ring size was varied from 10 to 16 amino acids. Alternative addition of basic and hydrophobic amino acids to the original GS10 construct generated a variety of even-numbered rings, i.e. GS10 [cyclo-(VKLdYPVKLdYP)], GS12 [cyclo-(VKLKdYPKVKLdYP)], GS14 [cyclo-(VKLKVdYPLKVKLdYP), and GS16 [cyclo-(VKLKVKdYPKLKVKLdYP)] (d stands for D-enantiomers). The odd-numbered analogs (11, 13 and 15-mers) were derived from these four peptides either by addition or deletion of single basic (Lys) or hydrophobic (Leu or Val) amino acids. The resulting peptides, divided into three groups on the basis of peptide ring size (10- to 12-meric, 13- and 14-meric, and 15- and 16-meric) illustrated a diverse spectrum of biological activity correlated to their ring size, degree of β-structure disruption, charge, hydrophobicity, amphipathicity and affinity for lipid membranes. Two of these peptides with potent antimicrobial activities and high therapeutic indexes (4.5–10 folds compared with GS) are promising candidates for development of broad-spectrum antibiotics.
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影响因子：
4.8
作者：
Kondejewski, LH;Jelokhani-Niaraki, M;Hodges, RS
通讯作者：
Hodges, RS
DOI：
10.1034/j.1399-3011.2001.00893.x
发表时间：
2001-10-01
期刊：
JOURNAL OF PEPTIDE RESEARCH
影响因子：
--
作者：
Jelokhani-Niaraki, M;Prenner, EJ;Hodges, RS
通讯作者：
Hodges, RS
影响因子：
3.4
作者：
Jelokhani-Niaraki, Masoud;Hodges, Robert S.;Wheaton, Laura
通讯作者：
Wheaton, Laura
影响因子：
4.8
作者：
Kondejewski, LH;Lee, DL;Hodges, RS
通讯作者：
Hodges, RS
影响因子：
64.8
作者：
HULL, SE;KARLSSON, R;DODSON, EJ
通讯作者：
DODSON, EJ