Correlation Between Serum Magnesium Level and Acute Exacerbation in Patients With Chronic Obstructive Pulmonary Disease (COPD).
Correlation Between Serum Magnesium Level and Acute Exacerbation in Patients With Chronic Obstructive Pulmonary Disease (COPD).
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DOI：
10.7759/cureus.26229
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发表时间：
2022-06
期刊：
影响因子：
--
通讯作者：
Sonagara M
中科院分区：
文献类型：
--
作者：
Makwana S;Patel A;Sonagara M
虽然慢性阻塞性肺疾病（COPD）是可以预防和治疗的，但它是一个主要的公共卫生问题。急性加重患者的死亡风险更高。镁（Mg）在许多生理过程中至关重要，包括膜稳定。然而，关于镁对COPD急性加重频率的影响，目前的信息不完整。目的探讨慢性阻塞性肺疾病（COPD）患者血清镁水平及其与COPD急性加重的关系。材料与方法这项横断面研究纳入了100名诊断为COPD急性加重的患者。所有COPD急性加重期患者入院时测定血清镁水平。血清镁水平<1.7 mg/dl被认为是低镁血症。血清镁水平与住院时间和患者预后的相关性进行了研究。结果在本研究中，低镁血症报告在57%的COPD急性加重患者。低镁血症患者住院时间超过7天者占80.7%，明显高于正常镁血症患者（55.8%）。低镁血症患者的死亡率高于正常镁血症患者，但无统计学意义。结论低镁血症是COPD急性加重期常见的临床表现。镁水平与COPD急性加重患者的住院时间有关，但与死亡率无关。需要更大样本量和更长随访期的进一步研究来验证结果。
Introduction Although chronic obstructive pulmonary disease (COPD) is preventable and treatable, it is a major public health problem. The mortality risks are higher in patients with exacerbations. Magnesium (Mg) is crucial in numerous physiological processes, including membrane stabilization. However, incomplete information is available regarding the effect of magnesium on the frequency of acute exacerbation of COPD. Objectives To determine the serum magnesium level in COPD patients and its correlation with acute exacerbation of COPD. Materials and methods This cross-sectional study included 100 patients diagnosed with acute exacerbation of COPD. The serum magnesium level was measured in all patients with acute exacerbation of COPD at admission. Serum Mg level <1.7 mg/dl was considered hypomagnesemia. The correlation between serum magnesium level and duration of hospital stay and patient outcome was studied. Results In the present study, hypomagnesemia was reported in 57% of patients with acute exacerbation of COPD. The duration of hospital stay (more than seven days) among hypomagnesemia (80.7%) patients was significantly higher than that of the normomagnesemia patients (55.8%). Mortality in patients with hypomagnesemia was higher than in patients with normomagnesemia, although not statistically significant. Conclusion Hypomagnesaemia is a common finding in acute exacerbation of COPD. The level of magnesium found is related to the length of hospital stay, but it is not related to mortality among patients with acute exacerbation of COPD. Further studies with larger sample sizes and extended follow-up periods are required to validate the results.
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影响因子：
4.3
作者：
Bhatt, Surya Prakash;Khandelwal, Pooja;Fioravanti, Gloria T.
通讯作者：
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DOI：
10.4103/0970-2113.164150
发表时间：
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期刊：
Lung India : official organ of Indian Chest Society
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作者：
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