CTLs: Killers of intracellular bacteria.
CTLs: Killers of intracellular bacteria.
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CTL：细胞内细菌的杀手
DOI：
10.3389/fcimb.2022.967679
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发表时间：
2022
影响因子：
5.7
通讯作者：
中科院分区：
文献类型：
--
作者：
许多微生物病原体已经进化出一系列逃避宿主免疫防御机制并在宿主细胞中存活和繁殖的能力。宿主细胞内细菌的存在使得特异性抗体难以发挥作用。细胞内的细菌逃脱吞噬细胞等先天免疫系统的攻击后，在细胞内存活，随后适应性免疫开始发挥作用。细胞毒性T淋巴细胞（CTL）在清除细胞内细菌中起重要作用。关键转录因子的调控可以促进CD 4 +/CD 8 + T细胞获得细胞溶解能力。TCR-CD 3复合物转导由TCR识别抗原产生的活化信号，并促进CTL产生多种途径杀死细胞内细菌。本文就CD 4/CD 8 CTL的分化机制以及CD 4/CD 8 CTL对细胞内细菌的杀伤作用作一综述。此外，还对它们在细菌感染治疗中的应用和前景进行了讨论。
Many microbial pathogens have evolved a range of capabilities to evade host immune defense mechanisms and to survive and multiply in host cells. The presence of host intracellular bacteria makes it difficult for specific antibodies to function. After the intracellular bacteria escape the attack of the innate immune system, such as phagocytes, they survive in cells, and then adaptive immunity comes into play. Cytotoxic T lymphocytes (CTLs) play an important role in eliminating intracellular bacteria. The regulation of key transcription factors could promote CD4+/CD8+ T cells to acquire cytolytic ability. The TCR-CD3 complex transduces activation signals generated by TCR recognition of antigen and promotes CTLs to generate multiple pathways to kill intracellular bacteria. In this review, the mechanism of CD4/CD8 CTLs differentiation and how CD4/CD8 CTLs kill intracellular bacteria are introduced. In addition, their application and prospects in the treatment of bacterial infections are discussed.
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DOI：
10.4049/jimmunol.1601231
发表时间：
2017-10-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Cheekatla SS;Tripathi D;Venkatasubramanian S;Paidipally P;Welch E;Tvinnereim AR;Nurieva R;Vankayalapati R
通讯作者：
Vankayalapati R
影响因子：
4.1
作者：
Lin Y;Dong Y;Gao Y;Shi R;Li Y;Zhou X;Liu W;Li G;Qi Y;Wu Y
通讯作者：
Wu Y
影响因子：
56.9
作者：
Butcher, EC;Picker, LJ
通讯作者：
Picker, LJ
影响因子：
56.9
作者：
Balint, S.;Muller, S.;Dustin, M. L.
通讯作者：
Dustin, M. L.
影响因子：
3.1
作者：
Delogu, G;Li, A;Morris, SL
通讯作者：
Morris, SL