Cross-sectional study of sleep quantity and quality and amnestic and non-amnestic cognitive function in an ageing population: the English Longitudinal Study of Ageing (ELSA).
Cross-sectional study of sleep quantity and quality and amnestic and non-amnestic cognitive function in an ageing population: the English Longitudinal Study of Ageing (ELSA).
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衰老人群中的睡眠数量和质量以及敏感和非遗传认知功能的横断面研究：英国的衰老纵向研究（ELSA）。
DOI：
10.1371/journal.pone.0100991
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Cappuccio FP
中科院分区：
文献类型：
--
作者：
Miller MA;Wright H;Ji C;Cappuccio FP
目的是调查老年人中年轻人和老年人的睡眠障碍与认知功能之间的关系。对来自英国老龄化纵向研究（艾尔莎）的3,968名男性和4,821名女性白色参与者进行了研究。Wave 4（2008）提供了关于睡眠质量和数量以及遗忘（记忆，ACF）和非遗忘（非记忆，nACF）功能的信息。采用协方差分析评价睡眠与认知功能的关系。在年轻组（50-64岁）中调整多个混杂因素后，睡眠持续时间解释了ACF的15.2%（p = 0.003）和nACF的20.6%（p = 0.010）。 在老年组（65岁以上）中，估计值分别为21.3%（p<0.001）和25.6%（p<0.001）。对于睡眠质量，在老年组中，睡眠质量与ACF（p<0.001）和nACF（p<0.001）之间存在统计学显著相关性，但在年轻组中没有相关性（分别为p= 0.586和p =0.373;研究样本中年龄和睡眠质量之间的相互作用包括两个年龄组：ACF p<0.001， nACF p =0.018）。 睡眠质量解释了认知差异的15.1%至25.5%。与年龄的相互作用是独立的睡眠时间。在任何水平的睡眠持续时间有一个陡峭的睡眠质量和ACF之间的关联，在老年人比年轻组。睡眠障碍和认知功能之间的关联在年轻人和老年人之间存在差异。前瞻性研究将确定不同年龄组的睡眠障碍和认知变化之间的时间关系。
The aim was to investigate the association between sleep disturbances and cognitive function in younger and older individuals from an ageing population. 3,968 male and 4,821 female white participants, aged 50 years and over, from the English Longitudinal Study of Ageing (ELSA) were studied. Information on sleep quality and quantity as well as both amnestic (memory, ACF) and non-amnestic (non-memory, nACF) function was available at Wave 4 (2008). Analysis of covariance was used to evaluate the relationship between sleep and cognitive function. After adjustment for multiple confounders in the younger group (50–64 years) duration of sleep explained 15.2% of the variance in ACF (p = 0.003) and 20.6% of nACF (p = 0.010). In the older group (65+ years) the estimates were 21.3% (p<0.001) and 25.6% (p<0.001), respectively. For sleep quality, there was a statistically significant association between sleep quality and both ACF (p<0.001) and nACF (p<0.001) in the older age group, but not in the younger age group (p = 0.586 and p = 0.373, respectively; interaction between age and sleep quality in the study sample including both age groups: p<0.001 for ACF and p = 0.018 for nACF). Sleep quality explained between 15.1% and 25.5% of the variance in cognition. The interaction with age was independent of duration of sleep. At any level of sleep duration there was a steeper association between sleep quality and ACF in the older than the younger group. The associations between sleep disturbances and cognitive function vary between younger and older adults. Prospective studies will determine the temporal relationships between sleep disturbances and changes in cognition in different age groups.
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