The effects of a single intravenous injection of novel activin A/BMP-2 (AB204) on toxicity and the respiratory and central nervous systems.
The effects of a single intravenous injection of novel activin A/BMP-2 (AB204) on toxicity and the respiratory and central nervous systems.
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DOI：
10.3109/01480545.2015.1092548
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发表时间：
2016
影响因子：
2.6
通讯作者：
Choe S
中科院分区：
文献类型：
--
作者：
Yoon BH;Lee JH;Na K;Ahn C;Cho J;Ahn HC;Choi J;Oh H;Kim BM;Choe S
本研究的目的是确定单次静脉注射一种新的骨诱导材料，激活素A/BMP-2（AB 204），对啮齿动物的毒性及其呼吸功能和中枢神经系统（CNS）的影响。SD大鼠单次静脉注射0、0.625、2.5和10 mg/kg剂量的AB 204，观察14 d的死亡率、一般症状。实验组也分别给予0.2，0.4和0.8 mg/kg的AB 204，并测量240 min的呼吸率，潮气量和每分钟通气量。实验组的印记控制区（ICR）小鼠分别给予单次静脉注射0.2，0.4和0.8 mg/kg的AB 204。测量体温，观察一般行为，评价AB 204对CNS的影响，持续240 min。单次静脉注射毒性研究发现，所有实验组均未出现死亡或异常症状，尸检结果异常，体重异常增加或减少。在呼吸率、潮气量、每分钟通气量、体温或一般行为方面未观察到与供试品相关的异常变化。根据这些结果，SD大鼠单次静脉注射AB 204的近似致死量超过10 mg/kg，SD大鼠单次静脉注射≤0.8 mg/kg AB 204对其呼吸系统无影响，ICR小鼠单次静脉注射对其CNS无影响。
The purpose of this study was to determine the effects of a single intravenous injection of a novel osteoinductive material, activin A/BMP-2 (AB204), to rodents on toxicity and their respiratory functions and central nervous system (CNS). A single intravenous injection of AB204 was given to Sprague–Dawley (SD) rats in doses of 0, 0.625, 2.5 and 10 mg/kg to observe the mortality rate, the general symptoms for 14 days. The experimental groups were also given 0.2, 0.4 and 0.8 mg/kg of AB204, respectively, and the respiration rate, the tidal volume and the minute volume were measured for 240 min. The experimental groups of imprinting control region (ICR) mice were given a single intravenous injection of 0.2, 0.4 and 0.8 mg/kg of AB204, respectively. Their body temperature was taken and general behaviors were observed to evaluate the effect of AB204 on the CNS for 240 min. The study on toxicity of a single intravenous injection found no death or abnormal symptoms, abnormal findings from autopsy, or abnormal body weight gain or loss in all the experimental groups. No abnormal variation associated with the test substance was observed in the respiration rate, the tidal volume, the minute volume, body temperature or the general behaviors. On the basis of these results, the approximate lethal dose of AB204 for a single intravenous injection exceeds 10 mg/kg for SD rats and a single intravenous injection of ≤0.8 mg/kg AB204 has no effect on their respiratory system for SD rat and no effect on their CNS for ICR mice.
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影响因子：
4.8
作者：
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通讯作者：
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