Biochemical Mechanisms of Sirtuin-Directed Protein Acylation in Hepatic Pathologies of Mitochondrial Dysfunction.
Biochemical Mechanisms of Sirtuin-Directed Protein Acylation in Hepatic Pathologies of Mitochondrial Dysfunction.
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线粒体蛋白乙酰化与许多疾病有关，包括癌症、阿尔茨海默氏症和代谢综合征。由于赖氨酸乙酰化靶向途径的复杂多样性，破译蛋白质乙酰化如何促进疾病病理学的机制仍然很困难。具体而言，蛋白质乙酰化被认为是直接反馈代谢，从而营养状况影响线粒体途径，包括β-氧化，柠檬酸循环和电子传递链。乙酰化提供了肝脏代谢和线粒体功能之间的重要联系。整个细胞中蛋白质乙酰化的失调可以改变线粒体功能，并且与许多肝脏疾病相关，包括非酒精性和酒精性脂肪性肝病、脂肪性肝炎和肝细胞癌。本文综述了蛋白质乙酰化在线粒体功能调节和肝脏疾病中的生化机制，并对靶向治疗的潜力提出了看法。
Mitochondrial protein acetylation is associated with a host of diseases including cancer, Alzheimer’s, and metabolic syndrome. Deciphering the mechanisms regarding how protein acetylation contributes to disease pathologies remains difficult due to the complex diversity of pathways targeted by lysine acetylation. Specifically, protein acetylation is thought to direct feedback from metabolism, whereby nutritional status influences mitochondrial pathways including beta-oxidation, the citric acid cycle, and the electron transport chain. Acetylation provides a crucial connection between hepatic metabolism and mitochondrial function. Dysregulation of protein acetylation throughout the cell can alter mitochondrial function and is associated with numerous liver diseases, including non-alcoholic and alcoholic fatty liver disease, steatohepatitis, and hepatocellular carcinoma. This review introduces biochemical mechanisms of protein acetylation in the regulation of mitochondrial function and hepatic diseases and offers a viewpoint on the potential for targeted therapies.
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SIRT3 线粒体脱乙酰酶在细胞生理学、癌症和神经退行性疾病中的功能。
影响因子：
7.8
作者：
Ansari A;Rahman MS;Saha SK;Saikot FK;Deep A;Kim KH
通讯作者：
Kim KH
DOI：
10.1111/acer.13473
发表时间：
2017-10
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
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通讯作者：
Fritz KS
影响因子：
4.6
作者：
Baldensperger, Tim;Eggen, Michael;Glomb, Marcus A.
通讯作者：
Glomb, Marcus A.
影响因子：
4.5
作者：
Botezelli, Jose Diego;Cambri, Lucieli Teresa;Rostom de Mello, Maria Alice
通讯作者：
Rostom de Mello, Maria Alice
DOI：
10.3390/antiox10040572
发表时间：
2021-04-08
期刊：
Antioxidants (Basel, Switzerland)
影响因子：
--
作者：
Bradshaw PC
通讯作者：
Bradshaw PC