Post-acute COVID-19 syndrome.

Post-acute COVID-19 syndrome.
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DOI:
10.1038/s41591-021-01283-z
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发表时间:
2021-04
期刊:
影响因子:
82.9
通讯作者:
Wan EY
Wan EY
中科院分区:
医学1区
文献类型:
--
作者:
Nalbandian A;Sehgal K;Gupta A;Madhavan MV;McGroder C;Stevens JS;Cook JR;Nordvig AS;Shalev D;Sehrawat TS;Ahluwalia N;Bikdeli B;Dietz D;Der-Nigoghossian C;Liyanage-Don N;Rosner GF;Bernstein EJ;Mohan S;Beckley AA;Seres DS;Choueiri TK;Uriel N;Ausiello JC;Accili D;Freedberg DE;Baldwin M;Schwartz A;Brodie D;Garcia CK;Elkind MSV;Connors JM;Bilezikian JP;Landry DW;Wan EY

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严重急性呼吸综合征冠状病毒2(SARS-CoV-2)是导致2019年冠状病毒病(新冠肺炎)大流行的病原体,已导致全球医疗危机和卫生资源紧张。随着新冠肺炎康复患者人数的增长,对他们周围的医疗问题建立一个了解是至关重要的。新冠肺炎现在被认为是一种具有广泛表现的多器官疾病。与其他强毒冠状病毒流行幸存者中描述的急性后病毒综合征类似,越来越多的报告表明,急性新冠肺炎之后会产生持续和长期的影响。患者权益倡导团体--其中许多成员自称是长途运输者--帮助人们认识到急性后新冠肺炎,这是一种自症状出现4周后持续出现症状和/或延迟或长期并发症的综合征。在这里,我们提供了一个全面的文献综述,目前关于急性新冠肺炎,其病理生理学和器官特异性后遗症。最后,我们讨论了新冠肺炎幸存者多学科护理的相关考虑,并提出了一个框架,用于识别急性期后新冠肺炎的高危人群,并通过专门的新冠肺炎诊所对他们进行协调管理。
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the pathogen responsible for the coronavirus disease 2019 (COVID-19) pandemic, which has resulted in global healthcare crises and strained health resources. As the population of patients recovering from COVID-19 grows, it is paramount to establish an understanding of the healthcare issues surrounding them. COVID-19 is now recognized as a multi-organ disease with a broad spectrum of manifestations. Similarly to post-acute viral syndromes described in survivors of other virulent coronavirus epidemics, there are increasing reports of persistent and prolonged effects after acute COVID-19. Patient advocacy groups, many members of which identify themselves as long haulers, have helped contribute to the recognition of post-acute COVID-19, a syndrome characterized by persistent symptoms and/or delayed or long-term complications beyond 4 weeks from the onset of symptoms. Here, we provide a comprehensive review of the current literature on post-acute COVID-19, its pathophysiology and its organ-specific sequelae. Finally, we discuss relevant considerations for the multidisciplinary care of COVID-19 survivors and propose a framework for the identification of those at high risk for post-acute COVID-19 and their coordinated management through dedicated COVID-19 clinics.
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