Cationic Contrast Agent Diffusion Differs Between Cartilage and Meniscus.
Cationic Contrast Agent Diffusion Differs Between Cartilage and Meniscus.
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DOI：
10.1007/s10439-016-1629-z
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发表时间：
2016-10
影响因子：
3.8
通讯作者：
Toyras, Juha
中科院分区：
文献类型：
--
作者：
Honkanen, Juuso T. J.;Turunen, Mikael J.;Freedman, Jonathan D.;Saarakkala, Simo;Grinstaff, Mark W.;Ylarinne, Janne H.;Jurvelin, Jukka S.;Toyras, Juha
关键词：
对比增强计算机断层扫描（CECT）是一种非破坏性成像技术，用于评估关节软骨和半月板的组成和结构。由于这些组织的结构和组成不同，造影剂在软骨和半月板中的扩散和分布可能不同。本研究的目的是确定一种新型碘基阳离子造影剂（CA2+）在软骨和半月板中的扩散运动学。取健康牛膝关节（n = 10）圆柱形软骨和半月板标本（d = 6 mm, h≈2 mm），浸泡在等渗阳离子造影剂（20 mgI/mL）中，在26个时间点使用微型ct扫描仪成像，持续48 h。随后，测定组织中标准化x射线衰减和造影剂扩散通量，以及水、胶原和蛋白多糖（PG）含量。对比剂在软骨和半月板内的分布不同。此外，归一化衰减和扩散通量在软骨中较高（p < 0.05）。基于这些结果，扩散运动学在软骨和半月板之间是不同的。这些组织特异性变化会影响CECT图像的解释，在同时评估软骨和半月板时应考虑到这一点。
Contrast enhanced computed tomography (CECT) is a non-destructive imaging technique used for the assessment of composition and structure of articular cartilage and meniscus. Due to structural and compositional differences between these tissues, diffusion and distribution of contrast agents may differ in cartilage and meniscus. The aim of this study is to determine the diffusion kinematics of a novel iodine based cationic contrast agent (CA2+) in cartilage and meniscus. Cylindrical cartilage and meniscus samples (d = 6 mm, h ≈ 2 mm) were harvested from healthy bovine knee joints (n = 10), immersed in isotonic cationic contrast agent (20 mgI/mL), and imaged using a micro-CT scanner at 26 time points up to 48 h. Subsequently, normalized X-ray attenuation and contrast agent diffusion flux, as well as water, collagen and proteoglycan (PG) contents in the tissues were determined. The contrast agent distributions within cartilage and meniscus were different. In addition, the normalized attenuation and diffusion flux were higher (p < 0.05) in cartilage. Based on these results, diffusion kinematics vary between cartilage and meniscus. These tissue specific variations can affect the interpretation of CECT images and should be considered when cartilage and meniscus are assessed simultaneously.
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影响因子：
3.8
作者：
Honkanen, J. T. J.;Turunen, M. J.;Toyras, J.
通讯作者：
Toyras, J.
影响因子：
2.2
作者：
Kulmala, K. A. M.;Korhonen, R. K.;Toyras, J.
通讯作者：
Toyras, J.
影响因子：
7
作者：
Kokkonen, H. T.;Makela, J.;Toyras, J.
通讯作者：
Toyras, J.
影响因子：
62.1
作者：
Lusic, Hrvoie;Grinstaff, Mark W.
通讯作者：
Grinstaff, Mark W.
影响因子：
7
作者：
Lakin, B. A.;Grasso, D. J.;Snyder, B. D.
通讯作者：
Snyder, B. D.