Mixed-Effect Time-Varying Network Model and Application in Brain Connectivity Analysis.

Mixed-Effect Time-Varying Network Model and Application in Brain Connectivity Analysis.
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DOI:
10.1080/01621459.2019.1677242
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发表时间:
2020
影响因子:
3.7
通讯作者:
Li L
Li L
中科院分区:
数学1区
文献类型:
--
作者:
Zhang J;Wei Sun W;Li L

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时变网络在广泛的科学和商业应用中迅速崛起。现有的动态网络模型大多局限于单主体和离散时间的环境。在这篇文章中,我们提出了一个混合效应的网络模型,在人口水平上的网络的连续时变行为的特征,同时考虑到个人的主题变异性以及先验模块信息。我们为约束似然估计开发了一个多步优化程序,并推导出相关的渐近性质。我们证明了我们的方法的有效性,通过模拟和应用到青年大脑发育的研究。本文的补充材料可在网上查阅。
Time-varying networks are fast emerging in a wide range of scientific and business applications. Most existing dynamic network models are limited to a single-subject and discrete-time setting. In this article, we propose a mixed-effect network model that characterizes the continuous time-varying behavior of the network at the population level, meanwhile taking into account both the individual subject variability as well as the prior module information. We develop a multistep optimization procedure for a constrained likelihood estimation and derive the associated asymptotic properties. We demonstrate the effectiveness of our method through both simulations and an application to a study of brain development in youth. Supplementary materials for this article are available online.
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