Antidiabetic activity of zinc oxide and silver nanoparticles on streptozotocin-induced diabetic rats.
Antidiabetic activity of zinc oxide and silver nanoparticles on streptozotocin-induced diabetic rats.
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DOI：
10.3390/ijms15022015
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发表时间：
2014-01-28
影响因子：
5.6
通讯作者：
Afifi M
中科院分区：
文献类型：
--
作者：
Alkaladi A;Abdelazim AM;Afifi M
纳米粒子在医学中的应用是一个有吸引力的提议。在本研究中，评估了氧化锌和银纳米颗粒的抗糖尿病活性。使用 50 只雄性白化大鼠，体重 120 ± 20，年龄 6 个月。动物分组如下：对照组；未接受任何类型的治疗，患有糖尿病；接受单次腹膜内剂量的链脲佐菌素（100 mg/kg）、糖尿病患者+氧化锌纳米颗粒（ZnONPs）、每日口服单次剂量的10 mg/kg ZnONPs悬浮液、糖尿病患者+银纳米颗粒（SNPs）；接受每日单次口服 SNP 悬浮液剂量 10 mg/kg 和糖尿病患者 + 胰岛素；接受单次皮下注射0.6单位/50克体重。在用氧化锌、纳米银颗粒和胰岛素治疗的糖尿病大鼠中，氧化锌和纳米银颗粒导致血糖显着降低、血清胰岛素升高、葡萄糖激酶活性升高、胰岛素、胰岛素受体、GLUT-2和葡萄糖激酶基因的表达水平升高。总之，氧化锌和纳米银颗粒可作为有效的抗糖尿病药物。
The use of nanoparticles in medicine is an attractive proposition. In the present study, zinc oxide and silver nanoparticles were evaluated for their antidiabetic activity. Fifty male albino rats with weight 120 ± 20 and age 6 months were used. Animals were grouped as follows: control; did not receive any type of treatment, diabetic; received a single intraperitoneal dose of streptozotocin (100 mg/kg), diabetic + zinc oxide nanoparticles (ZnONPs), received single daily oral dose of 10 mg/kg ZnONPs in suspension, diabetic + silver nanoparticles (SNPs); received a single daily oral dose of SNP of 10 mg/kg in suspension and diabetic + insulin; received a single subcutaneous dose of 0.6 units/50 g body weight. Zinc oxide and silver nanoparticles induce a significant reduced blood glucose, higher serum insulin, higher glucokinase activity higher expression level of insulin, insulin receptor, GLUT-2 and glucokinase genes in diabetic rats treated with zinc oxide, silver nanoparticles and insulin. In conclusion, zinc oxide and sliver nanoparticles act as potent antidiabetic agents.
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