p21-Activated Kinase: Role in Gastrointestinal Cancer and Beyond.
p21-Activated Kinase: Role in Gastrointestinal Cancer and Beyond.
复制标题
DOI：
10.3390/cancers14194736
复制
发表时间：
2022-09-28
期刊：
影响因子：
5.2
通讯作者：
Li, Feng
中科院分区：
文献类型：
--
作者：
Li, Xiaodong;Li, Feng
胃肠道肿瘤是全球最常见的肿瘤，死亡率很高。人们对许多蛋白激酶进行了研究，以期找到可行的肿瘤治疗靶点，包括 PAK。 PAK是一种丝氨酸/苏氨酸激酶，在肿瘤的恶性表型中发挥重要作用。 PAK在肿瘤中的作用突出表现在细胞增殖、存活、运动、肿瘤细胞可塑性和肿瘤微环境等方面，为临床肿瘤治疗提供了新的可能靶点。我们基于目前PAK的研究工作，总结分析了PAK的特性和细胞内的信号通路，特别是PAK在胃肠道肿瘤中的作用，希望为PAK的未来研究和潜在的肿瘤治疗靶点提供理论依据。胃肠道肿瘤是最常见的肿瘤，是全球癌症死亡的主要原因，但其机制仍不清楚，需要澄清以发现治疗靶点。 p21 激活激酶 (PAK) 是一种丝氨酸/苏氨酸激酶，位于 Rho GTPase 下游，在细胞信号传导网络中发挥着重要作用。根据其结构特征和激活机制，PAK分为两类，两类都参与细胞至关重要的生物过程，包括增殖、迁移、生存、转化和代谢。 PAK的生物学功能取决于大量相互作用的蛋白质及其参与的信号通路。PAK在肿瘤中的作用体现在它们的异常以及随之而来的信号通路的变化。一旦PAK过度表达或过度激活，就会导致肿瘤发生或恶性表型，特别是在肿瘤侵袭和转移中。最近，PAKs 在细胞可塑性、干性和肿瘤微环境中的参与引起了人们的关注。在此，我们总结了PAKs的生物学特性和关键信号通路，并进一步分析其在胃肠道肿瘤等中的作用机制，为胃肠道肿瘤的临床治疗揭示新的治疗靶点和理论基础。
Gastrointestinal tumors are the most common tumors with a high mortality rate worldwide. Numerous protein kinases have been studied in anticipation of finding viable tumor therapeutic targets, including PAK. PAK is a serine/threonine kinase that plays an important role in the malignant phenotype of tumors. The function of PAK in tumors is highlighted in cell proliferation, survival, motility, tumor cell plasticity and the tumor microenvironment, therefore providing a new possible target for clinical tumor therapy. Based on the current research works of PAK, we summarize and analyze the PAK features and signaling pathways in cells, especially the role of PAK in gastrointestinal tumors, thereby hoping to provide a theoretical basis for both the future studies of PAK and potential tumor therapeutic targets. Gastrointestinal tumors are the most common tumors, and they are leading cause of cancer deaths worldwide, but their mechanisms are still unclear, which need to be clarified to discover therapeutic targets. p21-activating kinase (PAK), a serine/threonine kinase that is downstream of Rho GTPase, plays an important role in cellular signaling networks. According to the structural characteristics and activation mechanisms of them, PAKs are divided into two groups, both of which are involved in the biological processes that are critical to cells, including proliferation, migration, survival, transformation and metabolism. The biological functions of PAKs depend on a large number of interacting proteins and the signaling pathways they participate in. The role of PAKs in tumors is manifested in their abnormality and the consequential changes in the signaling pathways. Once they are overexpressed or overactivated, PAKs lead to tumorigenesis or a malignant phenotype, especially in tumor invasion and metastasis. Recently, the involvement of PAKs in cellular plasticity, stemness and the tumor microenvironment have attracted attention. Here, we summarize the biological characteristics and key signaling pathways of PAKs, and further analyze their mechanisms in gastrointestinal tumors and others, which will reveal new therapeutic targets and a theoretical basis for the clinical treatment of gastrointestinal cancer.
登录
查看更多内容
P21 激活激酶 4 的过度表达与非小细胞肺癌的不良预后相关，并促进迁移和侵袭
DOI：
10.1186/s13046-015-0165-2
发表时间：
2015-05-15
期刊：
Journal of experimental & clinical cancer research : CR
影响因子：
--
作者：
Cai S;Ye Z;Wang X;Pan Y;Weng Y;Lao S;Wei H;Li L
通讯作者：
Li L
影响因子：
5.2
作者：
Alfarouk KO;Muddathir AK;Shayoub ME
通讯作者：
Shayoub ME
影响因子：
--
作者：
Cai S;Chen R;Li X;Cai Y;Ye Z;Li S;Li J;Huang H;Peng S;Wang J;Tao Y;Huang H;Wen X;Mo J;Deng Z;Wang J;Zhang Y;Gao X;Wen X
通讯作者：
Wen X
影响因子：
5.7
作者：
Chauhan SC;Ebeling MC;Maher DM;Koch MD;Watanabe A;Aburatani H;Lio Y;Jaggi M
通讯作者：
Jaggi M
影响因子：
11.2
作者：
Arias-Romero LE;Villamar-Cruz O;Huang M;Hoeflich KP;Chernoff J
通讯作者：
Chernoff J