Synaptic vesicles: is kissing a matter of competence?
Synaptic vesicles: is kissing a matter of competence?
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突触小泡：接吻是能力问题吗？
DOI：
10.1016/s0962-8924(01)02058-x
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发表时间：
2001
影响因子：
19
通讯作者：
Riccardo Fesce
中科院分区：
文献类型：
--
作者：
Flavia Valtorta;Jacopo Meldolesi;Riccardo Fesce
胞吐和内吞作用的“亲跑”模型预测突触囊泡在与质膜融合后可以进行快速有效的再循环，而不会混合膜。从几个新的实验方法中，越来越多的证据表明，接吻后逃跑发生在突触上。不同的囊泡池，最初是在形态方面确定的，现在是在生化和功能方面的特点。此外，至少有两种功能循环途径，在不同的时间尺度（从毫秒到几十秒）上运作，已被证明在同一突触系统中共存，这两种途径似乎受到不同的调节。综上所述，这些数据表明，“亲了就跑”与经典的包覆囊泡循环是并行的。在这里，我们回顾了最近的证据，吻和跑回收和讨论它是否是一个独特的过程，依赖于融合囊泡的分子组织。我们认为囊泡经历了一个“能力成熟”的过程。根据这一观点，囊泡的特定分子组成、它们的位置以及它们与神经末梢蛋白的相互作用可能不仅决定了囊泡融合和神经递质释放的不同可用性，还决定了它们将遵循的循环路径。
The ‘kiss-and-run' model of exocytosis and endocytosis predicts that synaptic vesicles can undergo fast and efficient recycling, after fusion with the plasmalemma, without intermixing of membranes. Evidence is mounting from several new experimental approaches that kiss-and-run occurs at synapses. Distinct vesicle pools, which initially were identified in morphological terms, are now being characterized in biochemical and functional terms. In addition, at least two functional recycling pathways, operating on different time scales (from milliseconds to tens of seconds), have been shown to coexist in the same synaptic system, and the two pathways appear to be differentially regulated. Taken together, these data suggest that kiss-and-run operates in parallel with the classical, coated-vesicle recycling. Here, we review recent evidence for kiss-and-run recycling and discuss whether it is a distinct process, dependent on the molecular organization of the fusing vesicle. We propose that vesicles undergo a process of ‘competence maturation'. According to this view, the specific molecular make-up of the vesicles, their location and their interactions with nerve terminal proteins might determine not only the differential availability of the vesicles for fusion and neurotransmitter release but also the recycling path that they will follow.
DOI：
10.1073/pnas.97.11.6120
发表时间：
2000-05-23
影响因子：
11.1
作者：
Daly, C;Sugimori, M;Llin치s, R
通讯作者：
Llin치s, R