Increasing dietary oat fibre decreases the permeability of intestinal mucus.
Increasing dietary oat fibre decreases the permeability of intestinal mucus.
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DOI：
10.1016/j.jff.2016.08.018
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发表时间：
2016-10
影响因子：
5.6
通讯作者：
Bajka, Balazs
中科院分区：
文献类型：
--
作者：
Mackie, Alan;Rigby, Neil;Harvey, Pascale;Bajka, Balazs
在猪中对强化β-葡聚糖饮食与对照饮食进行了比较。体外消化表明，90%的β-葡聚糖在近端小肠中溶解。增强型日粮猪肠道粘液的通透性降低。该结果对人类2型糖尿病危险因素具有影响。本研究探讨了膳食纤维β-葡聚糖对营养成分和粘液渗透性的影响。对猪饲喂标准饲料或含有两倍β-葡聚糖含量的饲料3天（每组n = 5），然后收集小肠粘液和组织样本。对消耗的饮食样品进行体外消化，以确定β-葡聚糖释放、营养成分和粘液渗透性评估。在体外消化的饮食表明，90%的β-葡聚糖释放在近端小肠。肠粘液的测量结果显示，对100 nm乳胶珠的渗透性降低，并且来自消化的增强β-葡聚糖饮食的脂质也降低。这项研究的数据首次表明，减少胆汁和脂质通过肠粘液层的质量转移可能是可溶性纤维减少胆汁重吸收的一种方式。
Comparison was made between an enhanced β-glucan diet versus a control diet in pigs. In vitro digestion showed that 90% of the β-glucan was solubilised in the proximal small intestine. The permeability of the intestinal mucus of the pigs on the enhanced diet was decreased. The results have implications for type two diabetes risk factors in humans. This study investigates the influence of the dietary fibre β-glucan on nutrient composition and mucus permeability. Pigs were fed a standard diet or a diet containing twice the β-glucan content for 3 days (n = 5 per group), followed by the collection of small intestinal mucus and tissue samples. Samples of the consumed diets were subjected to in vitro digestion to determine β-glucan release, nutrient profile and assessment of mucus permeability. In vitro digestion of the diets indicated that 90% of the β-glucan was released in the proximal small intestine. Measurements of intestinal mucus showed a reduction in permeability to 100 nm latex beads and also lipid from the digested enhanced β-glucan diet. The data from this study show for the first time that reducing mass transfer of bile and lipid through the intestinal mucus layer may be one way in which this decrease in bile reabsorption by soluble fibre is enabled.
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DOI：
10.5713/ajas.2005.1634
发表时间：
2005-11-01
期刊：
ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES
影响因子：
--
作者：
Morel, PCH;Melai, J;Coles, CD
通讯作者：
Coles, CD
影响因子：
5.2
作者：
Gunness, Purnima;Williams, Barbara A.;Gidley, Michael J.
通讯作者：
Gidley, Michael J.
影响因子：
5.2
作者：
Brennan, CS
通讯作者：
Brennan, CS
影响因子：
10.7
作者：
Brownlee, Iain A.
通讯作者：
Brownlee, Iain A.
影响因子：
3.4
作者：
Olmsted, SS;Padgett, JL;Cone, RA
通讯作者：
Cone, RA