Electrical stimulation of the midbrain excites the auditory cortex asymmetrically
Electrical stimulation of the midbrain excites the auditory cortex asymmetrically
复制标题
中脑的电刺激会不对称地兴奋听觉皮层
DOI：
10.1016/j.brs.2018.05.009
复制
发表时间：
2018
影响因子：
7.7
通讯作者：
Kral A
中科院分区：
文献类型：
--
作者：
Quass GL;Kurt S;Hildebrandt KJ;Kral A
背景听觉中脑植入物使用者不能实现开放的语音感知，并且具有有限的频率分辨率。目前还不清楚是否传播的兴奋有助于这个问题，以及它可以补偿多少电流聚焦，这是一种有效的方法，在人工耳蜗implants.E.M.本研究探讨了传播的兴奋在皮层引起的电中脑刺激。我们进一步测试是否通过双极和三极刺激电流聚焦是有效的电中脑刺激，以及这些模式是否持有任何优势，单极刺激也在条件下，当刺激电极直接接触的目标tissue.MethodsUsing穿透多电极阵列，我们记录了皮质人口的反应，单脉冲电中脑刺激10氯胺酮/甲苯噻嗪麻醉小鼠。我们比较了单极，双极和三极刺激配置方面的传播的激励和刺激/recording electrodes.ResultsThe皮质反应分布不对称的特征频率周围的刺激中脑区域的强烈激活的区域调谐到一个八度更高。我们发现单极，双极和三极刺激的阈值，诱发放电率，或动态范围之间没有显着差异。ConclusionThe皮层反应电中脑刺激偏向于更高的tonotopic频率。电流聚焦在直接接触电刺激中无效。电极图应考虑非对称传播的兴奋时，安装听觉中脑植入物的频带下移和刺激尽可能背。
BackgroundAuditory midbrain implant users cannot achieve open speech perception and have limited frequency resolution. It remains unclear whether the spread of excitation contributes to this issue and how much it can be compensated by current-focusing, which is an effective approach in cochlear implants.ObjectiveThe present study examined the spread of excitation in the cortex elicited by electric midbrain stimulation. We further tested whether current-focusing via bipolar and tripolar stimulation is effective with electric midbrain stimulation and whether these modes hold any advantage over monopolar stimulation also in conditions when the stimulation electrodes are in direct contact with the target tissue.MethodsUsing penetrating multielectrode arrays, we recorded cortical population responses to single pulse electric midbrain stimulation in 10 ketamine/xylazine anesthetized mice. We compared monopolar, bipolar, and tripolar stimulation configurations with regard to the spread of excitation and the characteristic frequency difference between the stimulation/recording electrodes.ResultsThe cortical responses were distributed asymmetrically around the characteristic frequency of the stimulated midbrain region with a strong activation in regions tuned up to one octave higher. We found no significant differences between monopolar, bipolar, and tripolar stimulation in threshold, evoked firing rate, or dynamic range.ConclusionThe cortical responses to electric midbrain stimulation are biased towards higher tonotopic frequencies. Current-focusing is not effective in direct contact electrical stimulation. Electrode maps should account for the asymmetrical spread of excitation when fitting auditory midbrain implants by shifting the frequency-bands downward and stimulating as dorsally as possible.
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DOI：
--
发表时间：
1999
期刊：
影响因子：
--
作者：
A. Grumet
通讯作者：
A. Grumet
影响因子：
2.1
作者：
Lenarz, Thomas;Lim, Hubert H.;Lenarz, Minoo
通讯作者：
Lenarz, Minoo
听觉扑动融合作为中枢作用药物作用的衡量标准：融合阈值的修改和适应刺激的影响。
DOI：
--
发表时间：
1967
期刊：
British Journal of Pharmacology and Chemotherapy
影响因子：
--
作者：
G. Besser
通讯作者：
G. Besser
下丘的层内刺激促进听觉皮层的频率特异性激活
影响因子：
4
作者：
B. Allitt;C. Benjaminsen;S. Morgan;A. Paolini
通讯作者：
A. Paolini
影响因子：
2.8
作者：
deSauvage, RC;daCosta, DL;Aran, JM
通讯作者：
Aran, JM