Structure and function of the ARH family of ADP-ribosyl-acceptor hydrolases.
Structure and function of the ARH family of ADP-ribosyl-acceptor hydrolases.
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ADP-核糖基受体水解酶 ARH 家族的结构和功能。
DOI：
10.1016/j.dnarep.2014.03.005
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发表时间：
2014-11
期刊：
影响因子：
3.8
通讯作者：
Moss, Joel
中科院分区：
文献类型：
--
作者：
Mashimo, Masato;Kato, Jiro;Moss, Joel
ADP-核糖基化是一种翻译后蛋白质修饰，其中ADP-核糖从烟酰胺腺嘌呤二核苷酸（NAD+）转移到特异性受体，从而改变其活性。ADP-核糖转移反应分为单-和多-（ADP-核糖基）化。细胞ADP-核糖基化水平受到将ADP-核糖转移至受体蛋白的酶（例如ADP-核糖基转移酶、聚-（ADP-核糖）聚合酶（PARP））和切割ADP-核糖与受体之间的键的酶（例如ADP-核糖基-受体水解酶（ARH）、聚-（ADP-核糖）糖水解酶（PARG））的严格调节，从而构成ADP-核糖基化循环。本文综述了ARH家族蛋白的研究进展。该家族包括具有相似大小（39 kDa）和氨基酸序列的三个成员（ARH 1 -3）。ARH 1催化单-（ADP-核糖基）化精氨酸的N-糖苷键的水解。ARH 3水解聚-（ADP-核糖）（PAR）和O-乙酰基-ADP-核糖。ARH 1和ARH 3的不同底物特异性有助于它们在细胞中的独特作用。基于ARH 1 −/−和ARH 3 −/−小鼠的表型分析，ARH 1参与细菌毒素的作用以及肿瘤发生。ARH 3参与PAR的降解，PAR是由PARP 1合成的，以响应氧化应激诱导的DNA损伤;这种水解反应抑制PAR介导的细胞死亡，这一途径称为parthanatos。
ADP-ribosylation is a post-translational protein modification, in which ADP-ribose is transferred from nicotinamide adenine dinucleotide (NAD+) to specific acceptors, thereby altering their activities. The ADP-ribose transfer reactions are divided into mono- and poly-(ADP-ribosyl)ation. Cellular ADP-ribosylation levels are tightly regulated by enzymes that transfer ADP-ribose to acceptor proteins (e.g. ADP-ribosyltransferases, poly-(ADP-ribose) polymerases (PARP)) and those that cleave the linkage between ADP-ribose and acceptor (e.g. ADP-ribosyl-acceptor hydrolases (ARH), poly-(ADP-ribose) glycohydrolases (PARG)), thereby constituting an ADP-ribosylation cycle. This review summarizes current findings related to the ARH family of proteins. This family comprises three members (ARH1-3) with similar size (39 kDa) and amino acid sequence. ARH1 catalyzes the hydrolysis of the N-glycosidic bond of mono-(ADP-ribosyl)ated arginine. ARH3 hydrolyzes poly-(ADP-ribose) (PAR) and O-acetyl-ADP-ribose. The different substrate specificities of ARH1 and ARH3 contribute to their unique roles in the cell. Based on a phenotype analysis of ARH1−/− and ARH3−/− mice, ARH1 is involved in the action by bacterial toxins as well as in tumorigenesis. ARH3 participates in the degradation of PAR that is synthesized by PARP1 in response to oxidative stress-induced DNA damage; this hydrolytic reaction suppresses PAR-mediated cell death, a pathway termed parthanatos.
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影响因子：
14.9
作者：
Gagné JP;Pic E;Isabelle M;Krietsch J;Ethier C;Paquet E;Kelly I;Boutin M;Moon KM;Foster LJ;Poirier GG
通讯作者：
Poirier GG
影响因子：
4.4
作者：
Chapman, John D.;Gagne, Jean-Philippe;Goodett, David R.
通讯作者：
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影响因子：
14.9
作者：
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通讯作者：
Hottiger MO
DOI：
10.1073/pnas.0606526103
发表时间：
2006-11-28
影响因子：
11.1
作者：
Andrabi, Shaida A.;Kim, No Soo;Dawson, Ted M.
通讯作者：
Dawson, Ted M.
影响因子：
4.8
作者：
Borra, MT;O'Neill, FJ;Denu, JM
通讯作者：
Denu, JM