Towards soft robotic devices for site-specific drug delivery
Towards soft robotic devices for site-specific drug delivery
复制标题
用于特定部位药物输送的软机器人设备
DOI：
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发表时间：
2015
影响因子：
3.1
通讯作者：
G. Alici
中科院分区：
文献类型：
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作者：
G. Alici
最近致力于建立各种药物递送系统(DDS)的大量研究工作，这些DDS是机械/物理、化学和生物/分子DDS。在本文中，我们报道了基于植入型和机器人给药系统组成的机械/物理系统的部位特异性给药(定点、受控、靶向或智能给药)的最新进展，指的是将药物或治疗剂运送到体内期望的位置，并根据需要释放它，与传统的给药方式如口服、肠外、跨粘膜、局部和吸入相比，毒性和副作用可以忽略不计。虽然我们特别关注机器人或自主DDS，它们可以重新编程，并以所需的时间和速度提供多剂量的药物，但我们简要介绍了植入型DDS，它们相对于机器人DDS发展得很好，以突出设计和性能要求，并调查与机器人DDS相关的问题。提出了与这两个DDS相关的关键研究问题，以描述我们面临的研究挑战，以便为临床和生物医学应用建立软机器人设备。
Considerable research efforts have recently been dedicated to the establishment of various drug delivery systems (DDS) that are mechanical/physical, chemical and biological/molecular DDS. In this paper, we report on the recent advances in site-specific drug delivery (site-specific, controlled, targeted or smart drug delivery are terms used interchangeably in the literature, to mean to transport a drug or a therapeutic agent to a desired location within the body and release it as desired with negligibly small toxicity and side effect compared to classical drug administration means such as peroral, parenteral, transmucosal, topical and inhalation) based on mechanical/physical systems consisting of implantable and robotic drug delivery systems. While we specifically focus on the robotic or autonomous DDS, which can be reprogrammable and provide multiple doses of a drug at a required time and rate, we briefly cover the implanted DDS, which are well-developed relative to the robotic DDS, to highlight the design and performance requirements, and investigate issues associated with the robotic DDS. Critical research issues associated with both DDSs are presented to describe the research challenges ahead of us in order to establish soft robotic devices for clinical and biomedical applications.
药物输送的高级材料和处理：过去和未来。
影响因子：
16.1
作者：
Zhang, Ying;Chan, Hon Fai;Leong, Kam W.
通讯作者：
Leong, Kam W.