Immune derangement occurs in patients with H7N9 avian influenza.
Immune derangement occurs in patients with H7N9 avian influenza.
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H7N9禽流感患者出现免疫紊乱
DOI：
10.1186/cc13788
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发表时间：
2014-03-24
期刊：
影响因子：
--
通讯作者：
Li L
中科院分区：
文献类型：
--
作者：
Wu W;Shi Y;Gao H;Liang W;Sheng J;Li L
IntroductionCurrently，little is known about the immunological characteristics of patients with avian influenza A（H7N9）virus infection.MethodsThe number and percentage of peripheral blood immune cells were measured in 27 patients with laboratory confirmed H7N9 virus infection and 30 healthy control（HC）.采用流式细胞仪检测T细胞和单核细胞功能表型及血清细胞因子水平。急性呼吸窘迫综合征13例（70.4%）继发呼吸道感染20例（48.1%），全身炎症反应综合征20例（74%）SIRS（定义为至少有两种并发SIRS组分），18例（66.7%）淋巴细胞减少，11例（40.7%）单核细胞数量减少。与HC组相比，IL-6、IL-8和IL-10水平及CD 38+和Tim-3+ T细胞百分比均显著升高。然而，人类白细胞抗原DR+和Tim-3+单核细胞的百分比显着降低患者相比，HCs.ConclusionsPatients与禽H7N9病毒感染显示深刻的SIRS伴随着抗炎反应，这可能与这种新的病毒性疾病的快速进展和高死亡率。
IntroductionCurrently, little is known about the immunological characteristics of patients with avian influenza A (H7N9) virus infection.MethodsThe numbers and percentages of peripheral blood immune cells were measured in 27 patients with laboratory-confirmed H7N9 virus infection and 30 healthy controls (HCs). The functional phenotypes of T cells and monocytes, as well as serum cytokine levels, were analyzed by flow cytometry.ResultsThere were 19 patients (70.4%) with acute respiratory distress syndrome, 13 (48.1%) with secondary respiratory infection, 20 (74%) with systemic inflammatory response syndrome (SIRS; defined as having at least two concurrent SIRS components), 18 (66.7%) with lymphocytopenia and 11 (40.7%) with reduced numbers of monocytes. In comparison with levels in the HCs, the levels of serum interleukin 6 (IL-6), IL-8 and IL-10 and the percentages of CD38+ or Tim-3+ T cells were significantly increased. However, the percentages of human leukocyte antigen-DR + and Tim-3+ monocytes were significantly decreased in patients compared with HCs.ConclusionsPatients with avian H7N9 virus infection display profound SIRS concomitantly with an anti-inflammatory response, which may be associated with the rapid progression of and high mortality associated with this novel viral disease.
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