A New Twist: The Combination of Sulbactam/Avibactam Enhances Sulbactam Activity against Carbapenem-Resistant Acinetobacter baumannii (CRAB) Isolates.
A New Twist: The Combination of Sulbactam/Avibactam Enhances Sulbactam Activity against Carbapenem-Resistant Acinetobacter baumannii (CRAB) Isolates.
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DOI：
10.3390/antibiotics10050577
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发表时间：
2021-05-13
期刊：
影响因子：
--
通讯作者：
Ramirez MS
中科院分区：
文献类型：
--
作者：
Pasteran F;Cedano J;Baez M;Albornoz E;Rapoport M;Osteria J;Montaña S;Le C;Ra G;Bonomo RA;Tolmasky ME;Adams M;Corso A;Ramirez MS
每年都有越来越多的无法治愈的感染病例。许多研究集中在开发新的β-内酰胺酶抑制剂来治疗多药耐药（MDR）菌株。在本研究中，针对187株多重耐药（MDR）不动杆菌临床分离株检测了舒巴坦/阿维巴坦和舒巴坦/曲塞巴坦复方制剂;舒巴坦/阿维巴坦和舒巴坦/曲塞巴坦均恢复了舒巴坦活性。当与阿维巴坦联合检测时，在89%的分离株中观察到舒巴坦MIC降低≥2个稀释度。舒巴坦/曲马巴坦能够恢复40%分离株的舒巴坦敏感性。此外，还对23株A.鲍曼不动杆菌AB 5075敲除菌株显示了潜在的舒巴坦和/或舒巴坦/阿维巴坦靶基因。我们观察到，二氮杂双环辛烷类（DBO）β-内酰胺酶抑制剂联合舒巴坦可恢复舒巴坦对碳青霉烯类耐药不动杆菌临床分离株的敏感性。然而，当与舒巴坦联合使用时，曲库巴坦不如阿维巴坦有效。探索新的组合可能为治疗不动杆菌属提供新的选择。感染，特别是广泛的苯唑西林酶和金属-β-内酰胺酶（MBL）生产者。
An increasing number of untreatable infections are recorded every year. Many studies have focused their efforts on developing new β-lactamase inhibitors to treat multi-drug resistant (MDR) isolates. In the present study, sulbactam/avibactam and sulbactam/relebactam combination were tested against 187 multi-drug resistant (MDR) Acinetobacter clinical isolates; both sulbactam/avibactam and sulbactam/relebactam restored sulbactam activity. A decrease ≥2 dilutions in sulbactam MICs was observed in 89% of the isolates when tested in combination with avibactam. Sulbactam/relebactam was able to restore sulbactam susceptibility in 40% of the isolates. In addition, the susceptibility testing using twenty-three A. baumannii AB5075 knockout strains revealed potential sulbactam and/or sulbactam/avibactam target genes. We observed that diazabicyclooctanes (DBOs) β-lactamase inhibitors combined with sulbactam restore sulbactam susceptibility against carbapenem-resistant Acinetobacter clinical isolates. However, relebactam was not as effective as avibactam when combined with sulbactam. Exploring novel combinations may offer new options to treat Acinetobacter spp. infections, especially for widespread oxacillinases and metallo-β-lactamases (MBLs) producers.
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影响因子：
4.9
作者：
Lomovskaya, Olga;Nelson, Kirk;Dudley, Michael N.
通讯作者：
Dudley, Michael N.
DOI：
10.1016/j.ram.2017.10.006
发表时间：
2018-09-01
期刊：
Revista argentina de microbiología
影响因子：
--
作者：
Rodríguez, Carlos Hernán;Nastro, Marcela;Famiglietti, Angela
通讯作者：
Famiglietti, Angela
影响因子：
4.8
作者：
Lin, David L.;Traglia, German M.;Tolmasky, Marcelo E.
通讯作者：
Tolmasky, Marcelo E.
影响因子：
11.8
作者：
Boucher, Helen W.;Talbot, George H.;Bartlett, John
通讯作者：
Bartlett, John
影响因子：
28.3
作者：
Durand-Reville, Thomas F.;Guler, Satenig;Miller, Alita A.
通讯作者：
Miller, Alita A.