Neuroprotective effect of S-allyl-l-cysteine derivatives against endoplasmic reticulum stress-induced cytotoxicity is independent of calpain inhibition.
Neuroprotective effect of S-allyl-l-cysteine derivatives against endoplasmic reticulum stress-induced cytotoxicity is independent of calpain inhibition.
复制标题
S-烯丙基-L-半胱氨酸衍生物对内质网应激诱导的细胞毒性的神经保护作用与钙蛋白酶抑制无关。
DOI：
10.1016/j.jphs.2016.03.004
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发表时间：
2016
期刊：
影响因子：
3.5
通讯作者：
Ito Y.
中科院分区：
文献类型：
--
作者：
Imai T;Kosuge Y;Saito H;Uchiyama T;Wada T;Shimba S;Ishige K;Miyairi S;Makishima M;Ito Y.
已知 S-烯丙基-L-半胱氨酸 (SAC) 具有神经保护特性。我们合成了各种 SAC 衍生物，并测试了它们对培养的海马神经元 (HPN) 内质网应激诱导的神经毒性的影响。在测试的化合物中，S-丙基-L-半胱氨酸（SPC）在HPNs中表现出最强的神经保护活性，其次是S-乙基-L-半胱氨酸（SEC）和S-甲基-L-半胱氨酸（SMC）。与SAC和SMC不同，SPC和SEC对μ-钙蛋白酶没有抑制活性，这表明SPC和SEC的保护活性机制与SAC不同。
S-allyl-l-cysteine (SAC) is known to have neuroprotective properties. We synthesized various SAC derivatives and tested their effects on endoplasmic reticulum stress-induced neurotoxicity in cultured hippocampal neurons (HPNs). Among the compounds tested,S-propyl-l-cysteine (SPC) exhibited the strongest neuroprotective activity in HPNs, followed byS-ethyl-l-cysteine (SEC) andS-methyl-l-cysteine (SMC). Unlike SAC and SMC, SPC and SEC did not have inhibitory activity on μ-calpain, suggesting that the mechanism underlying the protective activity of SPC and SEC differs from that of SAC.
影响因子：
4.2
作者：
Kosuge, Yasuhiro;Sakikubo, Taeko;Ito, Yoshihisa
通讯作者：
Ito, Yoshihisa
影响因子：
3.3
作者：
Imai, T.;Kosuge, Y.;Ito, Y.
通讯作者：
Ito, Y.
影响因子：
4.4
作者：
Moriguchi, T;Matsuura, H;Nishiyama, N
通讯作者：
Nishiyama, N